Bone
Non-neoplastic or metabolic disease
Hyperparathyroidism



Topic Completed: 1 June 2012

Revised: 27 December 2018

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: hyperparathyroidism[title]bone
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Cite this page: Borys D Hyperparathyroidism. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonehyperarathyroidism.html. Accessed March 24th, 2019.
Definition / general
  • Only 25% have bone disease, usually bone pain
  • Presents in young to middle - aged adults with recurring kidney stones, peptic ulcer, nausea, vomiting, weakness, headaches
  • Affects entire skeleton, cortical bone more than medullary bone
  • Usually detected early, so osteitis fibrosa cystica (severe changes, also called Recklinghausen’s disease) is rare
  • Skeletal abnormalities with secondary hyperparathyroidism are typically mild

Causes:
  • Parathyroid adenoma of one gland is most common
  • Rarely carcinoma or hyperplasia
Radiology description
  • Diffuse osteopenia
  • Specific pattern for fingers of cortical cutting cones (erosion of tufts of phalanges, subperiosteal cortical resorption, especially on radial side)
Laboratory
  • Marked hypercalcemia and hypophosphatemia
Gross description
Microscopic (histologic) description
  • Increased osteoclastic activity with tunneling of osteoclasts into bone matrix (dissecting resorption)
  • Also marked increase in bone formation and peritrabecular fibrosis
Differential diagnosis
  • Myelofibrosis: fibrous tissue diffusely throughout marrow, not around trabeculae
  • Paget's disease-acute phase: osteoclasts don’t tunnel, have more nuclei, different clinical presentation and laboratory findings
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