Non-neoplastic or metabolic disease
Hyperostosis cranii ex vacuo
Reviewers: Dariusz Borys, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Also called thickened calvarium
● May be due to intracranial hypotension associated with chronic shunting, as skull lacks the outward pressure needed to expand (Hum Pathol 1994;25:545)
● 23 year old woman with long standing ventriculoperitoneal shunt due to shaken baby syndrome
(Arch Pathol Lab Med 2003;127:94)
● Circumferentially thickened skull, particularly inner table, involvement of calvarium and base
● Increased cancellous space with normal trabecular bone
Figure 2B-increased cancellous space
Differential diagnosis of thickened calvarium
● Pagetís disease, fibrous dysplasia, thalassemia, hyperostosis frontalis interna (inner table has varying thickness of lobulated bone)
End of Bone > Non-neoplastic or metabolic disease > Hyperostosis cranii ex vacuo
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