Bone - Hyperostosis cranii ex vacuo

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Bone

Non-neoplastic or metabolic disease

Hyperostosis cranii ex vacuo

Reviewers: Dariusz Borys, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also called thickened calvarium
● May be due to intracranial hypotension associated with chronic shunting, as skull lacks the outward pressure needed to expand (Hum Pathol 1994;25:545)

Case reports
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● 23 year old woman with long standing ventriculoperitoneal shunt due to shaken baby syndrome (Arch Pathol Lab Med 2003;127:94)

Gross description
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● Circumferentially thickened skull, particularly inner table, involvement of calvarium and base

Gross images
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Thickened skull

Micro description
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● Increased cancellous space with normal trabecular bone

Micro images
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Figure 2B-increased cancellous space

Differential diagnosis of thickened calvarium
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● Paget’s disease, fibrous dysplasia, thalassemia, hyperostosis frontalis interna (inner table has varying thickness of lobulated bone)

End of Bone > Non-neoplastic or metabolic disease > Hyperostosis cranii ex vacuo

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