Bone
Other tumors of bone
Infantile myofibromatosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 19 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: infantile myofibromatosis [title] bone

Cite this page: Infantile myofibromatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneinfantilemyofibromatosis.html. Accessed December 9th, 2016.
Definition / General
  • Also called congenital fibromatosis, solitary infantile myofibromatosis
  • Rare; median age 16 months, range 6 months to 16 years
  • Solitary lesion in craniofacial bone, single nodule in soft tissue, multiple nodules in bone and soft tissue or diffuse involvement of viscera
Radiology Description
  • Well circumscribed bone lucency
  • Spontaneous resolution with good prognosis unless visceral involvement
Radiology Images
Images hosted on PathOut server:

Multifocal congenital xray - contributed by Dr. Mark R. Wick

Case Reports
Micro Description
  • Same as soft tissue myofibroma - proliferation of spindle cells with pink cytoplasm, myxoid background
  • Cells arranged in nodules with slit-like vascular spaces or hemangiopericytomatous pattern
Micro Images
Images hosted on PathOut server:

Multifocal congenital - contributed by Dr. Mark R. Wick

Differential Diagnosis
  • Sarcoma
Additional References