Bone
Fibrous and Fibroosseous tumors of bone
Liposclerosing myxofibrous tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 October 2016, last major update July 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Liposclerosing myxofibrous tumor[title]
Cite this page: Liposclerosing myxofibrous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneliposclerosingmyxofibrous.html. Accessed December 4th, 2016.
Definition / General
  • Also called polymorphic fibroosseous tumor of bone
  • Mixture of lipoma, fibroxanthoma, myxoma, myxofibroma, cyst formation, fat necrosis, ischemic ossification and fibrous dysplasia-like features
  • Mean age 40 years but also teens to 60’s
  • Usually incidental findings, but may gradually enlarge causing fracture, or occasionally undergo malignant transformation
  • Sites: 80% involve proximal femur; also ileum, humerus, rib
  • Some of these cases may be a variant of fibrous dysplasia with similar mutations (Hum Pathol 2003;34:1204)
  • 10% have malignant transformation
Radiology Description
  • Well-defined, lytic lesion with sclerotic margin, resembling bone infarct
Micro Description
  • Fat, xanthoma cells, cementum-like ossicles, Paget-type bone, myxofibrous tissue with cystic change
  • Curvilinear trabeculae in fibrous tissue in some cases
Additional References