Bone marrow nonneoplastic
Normal
Age related changes
Author: Dragos C. Luca, M.D.
Last author update: 1 September 2012
Last staff update: 13 December 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Bone marrow age related changes [title]
Table of Contents
Definition / general | Diagrams / tables | Gross images | Microscopic (histologic) imagesCite this page: Luca DC. Age related changes. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowagerelatedchanges.html. Accessed April 18th, 2024.
Definition / general
- Cellularity averages 79% at ages 0 - 9 years, 50% at ages 30 - 69 versus 29% at ages 70 - 79
- With aging, hematopoietic tissue is replaced by fat
- Deeper medullary areas are typically more cellular than subcortical areas
- B cell production declines with age (Curr Opin Immunol 2005;17:463) although the relative abundance of pro B, pre B, immature, naive and mature B cells usually does not change appreciably between ages 24 and 88 years
- Occasional patients have exceptionally low numbers of lymphocyte precursors (Blood 2003;101:576)
- Hypocellularity in elderly marrow may be due to increased apoptosis (Mech Ageing Dev 2000;117:57)
- Usually no spicules in bone marrow aspiration from very young children, perhaps due to very low or absent fat content
Diagrams / tables
Contributed by Dragos C. Luca, M.D.
Age related normal values in bone marrow
Gross images
Images hosted on other servers:
Fatty marrow
Microscopic (histologic) images
AFIP images
6 month old child has highly cellular marrow (normal for age)
Adult marrow (ages 30 - 69 years)
Images hosted on other servers:
Adult marrow
