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Bone marrow - nonneoplastic
Benign changes
Arsenic toxicity

Author: Xiangrong (Alex) Zhao, M.D., Ph.D. (see Reviewers page)
Revised: 23 July 2013, last major update July 2013
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
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Epidemiology
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Sites
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Pathophysiology
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Etiology
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Clinical features
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Diagnosis
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Uses by pathologists
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Case reports
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Treatment
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Clinical images
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Figure 1

Figure 2

Skin cancer


Fig 1: Pigment changes and palmoplantar hyperkeratoses are characteristic of chronic arsenic exposure
Fig 2: Arsenic keratosis-so called "raindrops on a dusty road”

Micro description
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Micro images-bone marrow
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Erythroid precursors have marked dysplastic changes including nuclear lobulation and karyorrhexis

Peripheral smear images
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Erythroid precursor with slightly lobulated megaloblastoid nucleus

Electron microscopy description
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Electron microscopy images
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Abnormal erythroblasts - see figure 2 (pdf)

Molecular / cytogenetics description
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Differential diagnosis
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End of Bone marrow - nonneoplastic > Benign changes > Arsenic toxicity


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