Bone marrow - nonneoplastic
Infectious / inflammatory
Candida

Author: Dragos Luca, M.D. (see Authors page)

Revised: 12 July 2017, last major update January 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Candida [title] bone marrow [title]

Cite this page: Candida. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowcandida.html. Accessed December 12th, 2017.
Definition / general
  • Fungal infections are rare in bone marrow and peripheral blood and almost exclusively occur in immunocompromised individuals
  • Candida albicans is one of the most common organisms
  • It dominates among patients with liver, kidney or pancreas transplants
  • Candida is also the most common fungal organism in immunocompetent patients with bone marrow granulomas
  • Disseminated candidiasis may be seen in newborns and is frequent in children treated for leukemia
  • Candida infection may promote granulopoiesis (Stem Cells Dev 2004;13:39)
Case reports
Treatment
Microscopic (histologic) description
  • Typically shows granuloma formation with or without associated central necrosis
  • In patients with underlying immunodeficiency, a diffuse histiocytic hyperplasia without distinct granuloma formation may be seen
  • Organisms are readily identifiable with GMS and PAS
  • In peripheral blood, fungal structures (budding yeasts, pseudohyphae) may be seen within granulocytes and monocytes or extracellularly
Microscopic (histologic) images

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Isolated bone marrow mycosis