Bone marrow - nonneoplastic
Systemic disorders

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 June 2017, last major update December 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Bone marrow cystinosis

Cite this page: Cystinosis. website. Accessed October 24th, 2018.
Definition / general
  • Nephrotic cystinosis is a rare autosomal disorder with defective cysteine transport out of lysosomes
Case reports
  • Cysteamine
Microscopic (histologic) description
  • Crystals in marrow histiocytes and giant cells
Microscopic (histologic) images

Images hosted on other servers:

Fig 1: bone marrow biopsy shows hypocellular marrow with numerous
macrophages containing hexagonal, tubular and rectangular cysteine crystals
Fig 2/3: crystals are birefringent using polarizing and first order compensator filters

Electron microscopy description
Electron microscopy images

Images hosted on other servers:

Normal platelets

Platelets contain variable dense granules

Platelet undergoing spontaneous release

Additional references