Bone marrow - nonneoplastic
Systemic disorders

Topic Completed: 1 December 2006

Revised: 8 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Bone marrow cystinosis

Nat Pernick, M.D.
Page views in 2018: 71
Page views in 2019 to date: 93
Cite this page: Pernick N. Cystinosis. website. Accessed December 6th, 2019.
Definition / general
  • Nephrotic cystinosis is a rare autosomal disorder with defective cysteine transport out of lysosomes
Case reports
  • Cysteamine
Microscopic (histologic) description
  • Crystals in marrow histiocytes and giant cells
Microscopic (histologic) images

Images hosted on other servers:

Fig 1: bone marrow biopsy shows hypocellular marrow with numerous
macrophages containing hexagonal, tubular and rectangular cysteine crystals
Fig 2/3: crystals are birefringent using polarizing and first order compensator filters

Electron microscopy description
Electron microscopy images

Images hosted on other servers:

Normal platelets

Platelets contain variable dense granules

Platelet undergoing spontaneous release

Additional references
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