Bone marrow - nonneoplastic
Systemic disorders
Cystinosis


Topic Completed: 1 December 2006

Revised: 8 August 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Bone marrow cystinosis

Nat Pernick, M.D.
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Cite this page: Pernick N. Cystinosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowcystinosis.html. Accessed December 6th, 2019.
Definition / general
  • Nephrotic cystinosis is a rare autosomal disorder with defective cysteine transport out of lysosomes
Case reports
Treatment
  • Cysteamine
Microscopic (histologic) description
  • Crystals in marrow histiocytes and giant cells
Microscopic (histologic) images

Images hosted on other servers:

Fig 1: bone marrow biopsy shows hypocellular marrow with numerous
macrophages containing hexagonal, tubular and rectangular cysteine crystals
Fig 2/3: crystals are birefringent using polarizing and first order compensator filters

Electron microscopy description
Electron microscopy images

Images hosted on other servers:

Normal platelets

Platelets contain variable dense granules

Platelet undergoing spontaneous release

Additional references
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