Bone marrow nonneoplastic
Alterations in cellularity
Hypercellularity
Author: Dragos C. Luca, M.D.
Last author update: 1 October 2013
Last staff update: 22 July 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Bone marrow hypercellular [title]
Table of Contents
Definition / general | Etiology | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Luca DC. Hypercellularity. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowhypercellularmarrow.html. Accessed April 24th, 2024.
Definition / general
- A finding, not a diagnosis
- Usually reactive (infection, blood loss) but also other benign or malignant causes
Etiology
- Benign causes:
- Affecting predominantly one hematopoietic line:
- Erythroid hyperplasia: often due to hemolytic anemia, high altitude or hypoxia of any other cause, renal disease, hemoglobinopathies, familial polycythemia
- Myeloid hyperplasia: infections, compensatory hyperplasia after cell destruction, chronic blood loss, other stressors, drugs (G-CSF)
- Megakaryocytic hyperplasia: often due to immune thrombocytopenia but also other types of thrombocytopenia; megakaryocytes may have striking nuclear changes
- Affecting predominantly one hematopoietic line:
- Malignant causes:
- Affecting predominantly one hematopoietic line:
- Erythroid: polycythemia vera, dysregulated erythropoietin production by various neoplasms
- Myeloid: myeloid neoplasms (AML, CML, MDS, other MPD besides CML)
- Megakaryocytic: MPD (essential thrombocythemia, CML, primary myelofibrosis), acute megakaryoblastic leukemia
- Affecting predominantly one hematopoietic line:
- Other causes include lymphoma, metastases
Microscopic (histologic) description
- Increased hematopoiesis
- Reduced adipose tissue
Microscopic (histologic) images
Images hosted on other servers:
Megaloblastic anemia
