Bone marrow - nonneoplastic
Infectious / inflammatory
Penicillium marneffei




Topic Completed: 01 December 2006

Revised: 9 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Bone marrow Penicillium marneffei

Page views in 2018: 697
Page views in 2019 to date: 32
Cite this page: Pernick N Penicillium marneffei. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowpenicilliosis.html. Accessed January 21st, 2019.
Definition / general
Treatment
  • Amphotericin B and itraconazole
Microscopic (histologic) description
  • Normo or hypercellular marrow
  • Intracytoplasmic organisms similar to histoplasma but also sausage cells with light blue cytoplasm and central cross walls (due to fission, not budding) and 1 or 2 purple red small nuclei
  • Normal or increased granulocyte and erythroid precursors
  • Normal megakaryocytes
Microscopic (histologic) images

Images hosted on other servers:

Spleen

Giemsa stain: septate yeast-like cells

Penicillium (A / C)
vs. Histoplasma
capsulatum
(B / D)

Skin: basophilic
microbes and nucleated
basophilic granules

Positive stains
Differential diagnosis
  • Histoplasmosis: budding, intracellular only, no septum; often different epidemiology