Bone marrow - nonneoplastic
Infectious / inflammatory
Penicillium marneffei

Topic Completed: 01 December 2006

Revised: 9 January 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Bone marrow Penicillium marneffei

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Cite this page: Pernick N Penicillium marneffei. website. Accessed January 21st, 2019.
Definition / general
  • Amphotericin B and itraconazole
Microscopic (histologic) description
  • Normo or hypercellular marrow
  • Intracytoplasmic organisms similar to histoplasma but also sausage cells with light blue cytoplasm and central cross walls (due to fission, not budding) and 1 or 2 purple red small nuclei
  • Normal or increased granulocyte and erythroid precursors
  • Normal megakaryocytes
Microscopic (histologic) images

Images hosted on other servers:


Giemsa stain: septate yeast-like cells

Penicillium (A / C)
vs. Histoplasma
(B / D)

Skin: basophilic
microbes and nucleated
basophilic granules

Positive stains
Differential diagnosis
  • Histoplasmosis: budding, intracellular only, no septum; often different epidemiology