Bone marrow - nonneoplastic
Infectious / inflammatory
Talaromyces marneffei

Topic Completed: 1 December 2006

Minor changes: 14 January 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Bone marrow Talaromyces marneffei

Nat Pernick, M.D.
Page views in 2019: 859
Page views in 2020 to date: 246
Cite this page: Pernick N. Talaromyces marneffei. website. Accessed May 26th, 2020.
Definition / general
  • Previously called Penicillium marneffei
  • Amphotericin B and itraconazole
Microscopic (histologic) description
  • Normo or hypercellular marrow
  • Intracytoplasmic organisms similar to histoplasma but also sausage cells with light blue cytoplasm and central cross walls (due to fission, not budding) and 1 or 2 purple red small nuclei
  • Normal or increased granulocyte and erythroid precursors
  • Normal megakaryocytes
Microscopic (histologic) images

Images hosted on other servers:

Giemsa stain: septate yeast-like cells

Penicillium (A / C)
vs. Histoplasma
(B / D)

Positive stains
Differential diagnosis
  • Histoplasmosis: budding, intracellular only, no septum; often different epidemiology
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