Bone marrow - nonneoplastic
Systemic disorders
Podophyllin toxicity



Topic Completed: 1 December 2006

Revised: 10 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Podophyllin toxicity


Nat Pernick, M.D.
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Cite this page: Pernick N Podophyllin toxicity. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowpodophyllin.html. Accessed October 21st, 2019.
Definition / general
  • Used as topical treatment of condyloma, although recommended to cease office based use due to toxicities (Sex Transm Infect 2001;77:409)
  • A mitotic spindle poison that binds microtubular proteins
  • Causes transient leukopenia and thrombocytopenia
  • Can also cause coma and death
Microscopic (histologic) description
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