Bone marrow nonneoplastic
Infectious / inflammatory
Q fever
Author: Nat Pernick, M.D.
Last author update: 1 December 2006
Last staff update: 2 August 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Bone marrow Q fever
Table of Contents
Definition / general | Case reports | Diagnosis | Radiology images | Microscopic (histologic) description | Microscopic (histologic) images | Electron microscopy images | Additional referencesCite this page: Pernick N. Q fever. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowqfever.html. Accessed April 16th, 2024.
Definition / general
- Due to Coxiella burnetii, a rickettsiae usually not identifiable directly (Am J Surg Pathol 1985;9:752)
- Acute primary Q fever is essentially benign but may evolve into subacute Q fever endocarditis or a postinfectious fatigue syndrome
- Organism persists in bone marrow for years (QJM 2005;98:7, Epidemiol Infect 2000;124:543)
Case reports
- 71 year old man with malaise, fever, sweats (N Engl J Med 2006;354:1937)
Diagnosis
- PCR or serology
Radiology images
Images hosted on other servers:
Q fever meningoencephalitis
Q fever pneumonia
Microscopic (histologic) description
- Suggestive finding is a fibrin ring / doughnut granuloma defined as a small, nonnecrotizing granuloma with ring-like structure composed of fibrinoid material, often with a central fat vacuole (Arch Pathol Lab Med 1986;110:1017)
- Rarely hemophagocytosis (Clin Infect Dis 1995;21:1029)
Microscopic (histologic) images
Images hosted on other servers:
Fibrin ring granuloma with central fatty vacuoles
Liver: fibrin ring granuloma
Liver: doughnut granuloma
Cardiac valve
Liver: doughnut granuloma (arrow)
Cell lines infected with C. burnetii
Electron microscopy images
Images hosted on other servers:
Within vacuole of host cell
Additional references
