Bone marrow - nonneoplastic
Systemic disorders
Sea blue histiocytosis (syndrome)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 June 2017, last major update December 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sea blue histiocytosis bone marrow

Cite this page: Sea blue histiocytosis (syndrome). website. Accessed October 24th, 2018.
Definition / general
  • Clinical syndrome is associated with splenomegaly, mild thrombocytopenia and bone marrow involvement
  • Many reports using the term "syndrome" are actually reporting just a microscopic finding
  • Microscopic finding is associated with various hematologic and systemic disorders, including:
Case reports
Microscopic (histologic) description
  • Histiocytes have cytoplasm filled with globules / granules of varying size containing blue or blue green pigment (Romanowsky stain) or yellow tan pigment (H&E)
Microscopic (histologic) images

Images hosted on other servers:

Chronic myelogenous leukemia

Refractory anemia with excess blasts

Refractory anemia with excess blasts in transformation

Positive stains
Electron microscopy description
  • Myelin figures
Electron microscopy images

Images hosted on other servers:

Hyperlipidemia: cytoplasmic electron dense granules

"Finger print" arrangement of membranes

Differential diagnosis
Additional references