Bone marrow - nonneoplastic
Systemic disorders
Sea blue histiocytosis (syndrome)


Topic Completed: 1 December 2006

Revised: 8 August 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Sea blue histiocytosis bone marrow

Nat Pernick, M.D.
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Cite this page: Pernick N. Sea blue histiocytosis (syndrome). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowseablue.html. Accessed December 6th, 2019.
Definition / general
  • Clinical syndrome is associated with splenomegaly, mild thrombocytopenia and bone marrow involvement
  • Many reports using the term "syndrome" are actually reporting just a microscopic finding
  • Microscopic finding is associated with various hematologic and systemic disorders, including:
Case reports
Microscopic (histologic) description
  • Histiocytes have cytoplasm filled with globules / granules of varying size containing blue or blue green pigment (Romanowsky stain) or yellow tan pigment (H&E)
Microscopic (histologic) images

Images hosted on other servers:

Chronic myelogenous leukemia

Refractory anemia with excess blasts

Refractory anemia with excess blasts in transformation

Positive stains
Electron microscopy description
  • Myelin figures
Electron microscopy images

Images hosted on other servers:

Hyperlipidemia: cytoplasmic electron dense granules

"Finger print" arrangement of membranes

Differential diagnosis
Additional references
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