Bone marrow - nonneoplastic
Systemic disorders
Sickle cell disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 June 2017, last major update December 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sickle cell disease [title] bone marrow [title]

Cite this page: Sickle cell disease. website. Accessed October 24th, 2018.
Definition / general
  • High sinusoidal blood flow in bone marrow predisposes it to blood stasis, causing regional hypoxia, acidosis, sickling and then thrombosis and infarction
  • Other complications are osteomyelitis and avascular necrosis
Diagrams / tables

Images hosted on other servers:


Case reports
Microscopic (histologic) description
  • May have increased normoblasts and megaloblastic changes due to folate deficiency
  • Increased perivascular fibrosis in small and medium sized vessels (Arch Pathol Lab Med 2004;128:634)
  • Occasional aplastic crisis
Microscopic (histologic) images

Images hosted on other servers:


Infarction of medullary cavity

Peripheral smear images

Images hosted on other servers:

Sickled erythrocytes

Positive stains
Additional references