Bone marrow nonneoplastic
Noninfectious systemic disorders
Sickle cell disease
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2006
Minor changes: 9 June 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Sickle cell disease [title] bone marrow [title]
Table of Contents
Definition / general | Diagrams / tables | Case reports | Clinical features | Microscopic (histologic) description | Microscopic (histologic) images | Peripheral smear images | Positive stains | Additional referencesCite this page: Pernick N. Sickle cell disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowsicklecelldisease.html. Accessed July 2nd, 2020.
Definition / general
- High sinusoidal blood flow in bone marrow predisposes it to blood stasis, causing regional hypoxia, acidosis, sickling and then thrombosis and infarction
- Other complications are osteomyelitis and avascular necrosis
Diagrams / tables
Images hosted on other servers:
Pathophysiology
Case reports
- 8 month old girl with sickle cell disease and Salmonella osteomyelitis (Ned Tijdschr Geneeskd 2004;148:1695)
- 23 year old man with sickle cell crisis associated with hemophagocytic lymphohistiocytosis (Am J Hematol 2004;77:229)
- Man with extensive bone marrow necrosis as presenting manifestation of sickle cell disease in Africa (Med Trop (Mars) 2004;64:179)
Clinical features
Microscopic (histologic) description
- May have increased normoblasts and megaloblastic changes due to folate deficiency
- Increased perivascular fibrosis in small and medium sized vessels (Arch Pathol Lab Med 2004;128:634)
- Occasional aplastic crisis
Microscopic (histologic) images
Images hosted on other servers:
Fibrosis
Infarction of medullary cavity
Peripheral smear images
Images hosted on other servers:
Sickled erythrocytes
Positive stains
- CD1a, CD1b and CD1c in monocytes (Hum Immunol 2004;65:1370)
Additional references
