Bone marrow - nonneoplastic
Systemic disorders
Sickle cell disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 June 2017, last major update December 2006

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PubMed Search: Sickle cell disease [title] bone marrow [title]

Cite this page: Sickle cell disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemarrowsicklecelldisease.html. Accessed July 22nd, 2017.
Definition / general
  • High sinusoidal blood flow in bone marrow predisposes it to blood stasis, causing regional hypoxia, acidosis, sickling and then thrombosis and infarction
  • Other complications are osteomyelitis and avascular necrosis
Diagrams / tables

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Pathophysiology

Case reports
Microscopic (histologic) description
  • May have increased normoblasts and megaloblastic changes due to folate deficiency
  • Increased perivascular fibrosis in small and medium sized vessels (Arch Pathol Lab Med 2004;128:634)
  • Occasional aplastic crisis
Microscopic (histologic) images

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Fibrosis

Infarction of medullary cavity

Peripheral smear images

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Sickled erythrocytes

Positive stains
Additional references