Bone marrow - nonneoplastic
Systemic disorders
Sickle cell disease

Topic Completed: 1 December 2006

Revised: 8 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Sickle cell disease [title] bone marrow [title]

Nat Pernick, M.D.
Page views in 2019: 1,072
Page views in 2020 to date: 331
Cite this page: Pernick N. Sickle cell disease. website. Accessed April 7th, 2020.
Definition / general
  • High sinusoidal blood flow in bone marrow predisposes it to blood stasis, causing regional hypoxia, acidosis, sickling and then thrombosis and infarction
  • Other complications are osteomyelitis and avascular necrosis
Diagrams / tables

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Case reports
Microscopic (histologic) description
  • May have increased normoblasts and megaloblastic changes due to folate deficiency
  • Increased perivascular fibrosis in small and medium sized vessels (Arch Pathol Lab Med 2004;128:634)
  • Occasional aplastic crisis
Microscopic (histologic) images

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Infarction of medullary cavity

Peripheral smear images

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Sickled erythrocytes

Positive stains
Additional references
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