Bone marrow nonneoplastic
Noninfectious systemic disorders
Sickle cell disease

Topic Completed: 1 December 2006

Minor changes: 9 June 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Sickle cell disease [title] bone marrow [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Sickle cell disease. website. Accessed July 2nd, 2020.
Definition / general
  • High sinusoidal blood flow in bone marrow predisposes it to blood stasis, causing regional hypoxia, acidosis, sickling and then thrombosis and infarction
  • Other complications are osteomyelitis and avascular necrosis
Diagrams / tables

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Case reports
Clinical features
  • Associated with increases in thrombin generation, fibrinolytic activation, platelet activation, increased antiphospholipid antibodies, decreased levels of circulating anticoagulants and contact factors
  • Also increased circulating levels of tissue factor and endothelial cells expressing a tissue factor phenotype
  • Have hypercoagulable state based on thermoelastographic profiles (Arch Pathol Lab Med 2005;129:760, J Clin Pathol 1980;33:622) <
  • Microscopic (histologic) description
    • May have increased normoblasts and megaloblastic changes due to folate deficiency
    • Increased perivascular fibrosis in small and medium sized vessels (Arch Pathol Lab Med 2004;128:634)
    • Occasional aplastic crisis
    Microscopic (histologic) images

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    Infarction of medullary cavity

    Peripheral smear images

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    Sickled erythrocytes

    Positive stains
    Additional references
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