Bone marrow - nonneoplastic
Infectious / inflammatory
Whipple disease

Topic Completed: 01 December 2006

Revised: 9 January 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Bone marrow Whipple disease

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Cite this page: Pernick N Whipple disease. website. Accessed January 21st, 2019.
Definition / general
  • Chronic inflammatory disease due to Tropheryma whipplei bacteria
  • Usually affects small intestine
  • PAS+ foamy macrophages
  • Electron microscopy
  • PCR
Case reports
Microscopic (histologic) description
  • Noncaseating granulomas
  • Numerous foamy macrophages containing PAS+ diastase resistant bacteria
Microscopic (histologic) images

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PAS staining

PAS, oil immersion

Grocott, oil immersion


Immunofluorescence (blue - bacteria, green - nuclei, red - vimentin)

Lymph node

Positive stains
  • PAS+ diastase resistant bacterial inclusions within macrophages
  • CD68 and other macrophage markers
Electron microscopy description
  • Bacilli within membrane bound vesicles
Electron microscopy images

Images hosted on other servers:

Whipple disease, duodenum

T. whipplei bacteria

Bacterium (arrowhead)