Bone marrow - nonneoplastic
Infectious / inflammatory
Whipple disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 July 2017, last major update December 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Bone marrow Whipple disease

Cite this page: Whipple disease. website. Accessed October 15th, 2018.
Definition / general
  • Chronic inflammatory disease due to Tropheryma whipplei bacteria
  • Usually affects small intestine
  • PAS+ foamy macrophages
  • Electron microscopy
  • PCR
Case reports
Microscopic (histologic) description
  • Noncaseating granulomas
  • Numerous foamy macrophages containing PAS+ diastase resistant bacteria
Microscopic (histologic) images

Images hosted on other servers:

PAS staining

PAS, oil immersion

Grocott, oil immersion


Immunofluorescence (blue - bacteria, green - nuclei, red - vimentin)

Lymph node

Positive stains
  • PAS+ diastase resistant bacterial inclusions within macrophages
  • CD68 and other macrophage markers
Electron microscopy description
  • Bacilli within membrane bound vesicles
Electron microscopy images

Images hosted on other servers:

Whipple disease, duodenum

T. whipplei bacteria

Bacterium (arrowhead)