Other tumors of bone

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: melorheostosis [title] bone

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Cite this page: Melorheostosis. website. Accessed December 18th, 2018.
Definition / general
  • Also called Leri's disease, flowing periosteal hyperostosis
  • Usually apparent in early childhood, 50% develop symptoms by age 20
  • Incidence of 0.9 cases per million
  • May have associated vascular malformations or hemangiomas, aneurysms, neurofibromatosis, linear scleroderma, tuberous sclerosis, focal subcutaneous fibrosis
  • Causes pain, joint stiffness, progressive deformity
Radiology description
  • Sclerotic bone lesions that resemble dripping wax
Microscopic (histologic) description
  • Variable marrow fibrosis, markedly irregular bone with mixed lamellar and woven bone
  • Soft tissue masses with osteocartilagenous, fibrovascular and adipose tissue