Melorheostosis

Bone
Other tumors of bone
Melorheostosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: melorheostosis [title] bone

Table of Contents

Definition / general | Radiology description | Microscopic (histologic) description

Cite this page: Melorheostosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemeloreostosis.html. Accessed July 14th, 2017.

Definition / general

Also called Leri's disease, flowing periosteal hyperostosis
Usually apparent in early childhood, 50% develop symptoms by age 20
Incidence of 0.9 cases per million
May have associated vascular malformations or hemangiomas, aneurysms, neurofibromatosis, linear scleroderma, tuberous sclerosis, focal subcutaneous fibrosis
Causes pain, joint stiffness, progressive deformity

Radiology description

Sclerotic bone lesions that resemble dripping wax

Microscopic (histologic) description

Variable marrow fibrosis, markedly irregular bone with mixed lamellar and woven bone
Soft tissue masses with osteocartilagenous, fibrovascular and adipose tissue