Bone
Other tumors of bone
Melorheostosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: melorheostosis [title] bone

Cite this page: Melorheostosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemeloreostosis.html. Accessed December 10th, 2016.
Definition / General
  • Also called Leri's disease, flowing periosteal hyperostosis
  • Usually apparent in early childhood, 50% develop symptoms by age 20
  • Incidence of 0.9 cases per million
  • May have associated vascular malformations or hemangiomas, aneurysms, neurofibromatosis, linear scleroderma, tuberous sclerosis, focal subcutaneous fibrosis
  • Causes pain, joint stiffness, progressive deformity
Radiology Description
  • Sclerotic bone lesions that resemble dripping wax
Micro Description
  • Variable marrow fibrosis, markedly irregular bone with mixed lamellar and woven bone
  • Soft tissue masses with osteocartilagenous, fibrovascular and adipose tissue