Bone
Other tumors of bone
Melorheostosis



Topic Completed: 1 June 2005

Revised: 3 January 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed search: melorheostosis [title] bone


Nat Pernick, M.D.
Page views in 2018: 225
Page views in 2019 to date: 295
Cite this page: Pernick N Melorheostosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemeloreostosis.html. Accessed October 21st, 2019.
Definition / general
  • Also called Leri's disease, flowing periosteal hyperostosis
  • Usually apparent in early childhood, 50% develop symptoms by age 20
  • Incidence of 0.9 cases per million
  • May have associated vascular malformations or hemangiomas, aneurysms, neurofibromatosis, linear scleroderma, tuberous sclerosis, focal subcutaneous fibrosis
  • Causes pain, joint stiffness, progressive deformity
Radiology description
  • Sclerotic bone lesions that resemble dripping wax
Microscopic (histologic) description
  • Variable marrow fibrosis, markedly irregular bone with mixed lamellar and woven bone
  • Soft tissue masses with osteocartilagenous, fibrovascular and adipose tissue
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