Chondrogenic tumors - chondrosarcoma

Topic Completed: 1 June 2005

Minor changes: 29 October 2019

Copyright: (c) 2003-2018,, Inc.

PubMed search: mesenchymal chondrosarcoma [title] bone

Nat Pernick, M.D.
Page views in 2019: 1,855
Page views in 2020 to date: 846
Cite this page: Pernick N Mesenchymal. website. Accessed June 4th, 2020.
Definition / general
  • Cartilaginous tumor with primitive component composed of mesenchymal cells at condensation stage
  • Rare; usually teenagers or young adults; no significant gender preference
  • Unpredictable prognosis; may have short or prolonged survival after metastases
  • Initial study suggests SOX9 is specific for this tumor versus other small blue cell tumors (Hum Pathol 2003;34:263)
  • Sites: diaphysis of jaw, pelvis, femur, ribs, spine; often involves extraosseous structures such as orbit, paraspinal region, meninges, extremity soft tissue
Radiology description
  • Resembles conventional chondrosarcoma
Radiology images

Expansile, predominantly lytic lesion

Gross description
  • Pink, fleshy, with calcification
  • Resembles other sarcomas
Gross images

Distal femur

Microscopic (histologic) description
  • Dimorphic pattern of well differentiated cartilage with abrupt boundary from undifferentiated stroma composed of small round / oval cells resembling lymphoma, hemangiopericytoma or Ewing's sarcoma / PNET
  • Occasional spindle cells
  • Minimal pleomorphism, no / rare mitotic figures
Microscopic (histologic) images

Neoplastic cells

Low power

Well defined island of low grade cartilage

Tumor cells separated by collagen

Dense cellularity

Contributed by Dr. Mark R. Wick

Positive stains
Negative stains
Molecular / cytogenetics description
  • Translocation der(13;21)(q10:q10) identified in 2 patients with skeletal and extraskeletal tumors (Mod Pathol 2002;15:572)
Differential diagnosis
Additional references
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