Bone
Bone forming tumors (not osteosarcoma)
Metastatic calcification

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 October 2016, last major update July 2013,

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Metastatic calcification[title]
Cite this page: Metastatic calcification. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemetcalcification.html. Accessed December 4th, 2016.
Definition / General
  • Also called calcium hydroxyapatite deposition in soft tissue, tumoral calcinosis
  • Associated with trauma, renal failure, hyperparathyroidism, metastatic carcinoma, myeloma, scleroderma, hypermetabolic states, sarcoidosis
  • In blacks, associated with elevated serum phosphate, occurs in teens with painless masses in hips, elbows, shoulders, gluteal area
  • Sites: kidney, alveoli of lungs, cornea, conjunctiva, gastric mucosa, blood vessel walls
Case Reports
  • Seven siblings with bleeding, then aggregation of foamy histiocytes, then cystic cavities lined by osteoclast-like giant cells (Am J Surg Pathol 1993;17:788)
Micro Description
  • Calcium deposits are associated with inflammatory cells and giant cells
Differential Diagnosis
  • Dystrophic calcification: dead tissue that is not rapidly absorbed; associated with coagulation necrosis, caseous necrosis, fat necrosis