Bone chapter (nontumor and tumor)
Bone forming tumors other than osteosarcoma
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 31 July 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Also called calcium hydroxyapatite deposition in soft tissue, tumoral calcinosis
- Associated with trauma, renal failure, hyperparathyroidism, metastatic carcinoma, myeloma, scleroderma, hypermetabolic states, sarcoidosis
- In blacks, associated with elevated serum phosphate, occurs in teens with painless masses in hips, elbows, shoulders, gluteal area
- Sites: kidney, alveoli of lungs, cornea, conjunctiva, gastric mucosa, blood vessel walls
- Seven siblings with bleeding, then aggregation of foamy histiocytes, then cystic cavities lined by osteoclast-like giant cells (Am J Surg Pathol 1993;17:788)
- Calcium deposits are associated with inflammatory cells and giant cells
- Dystrophic calcification: dead tissue that is not rapidly absorbed; associated with coagulation necrosis, caseous necrosis, fat necrosis
End of Bone chapter (nontumor and tumor) > Bone forming tumors other than osteosarcoma > Metastatic calcification
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