Bone
Other tumors of bone
Metastases to bone

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: "metastases to bone" [title]

Cite this page: Metastases to bone. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemetstobone.html. Accessed December 10th, 2016.
Definition / General
  • Most common malignant bone tumor is metastatic carcinoma
  • In adults, 80% from prostate, breast, kidney, lung or thyroid
  • In children, from neuroblastoma, Wilm tumor, osteosarcoma, Ewing / PNET or rhabdomyosarcoma
  • Intraspinal seeding may occur along Batson’s plexus of veins
  • Positive isotope bone scans (versus myeloma)
  • Sarcomatoid carcinoma: consider if patient 60+ years with spindling bone malignancy; cells usually plumper than bone sarcomas and accompanied by carcinoma; renal cell carcinoma is most common primary site
  • Common sites: axial skeleton, proximal femur, proximal humerus; usually marrow; very rare to be distal to elbow or knee
  • Solitary metastases: kidney, thyroid
  • Small bones of hands and feet: colon, lung, kidney
  • Blastic lesions: prostate, carcinoid tumor, neuroendocrine tumors
Radiology Images
Images hosted on PathOut server:

Breast carcinoma - contributed by Dr. Mark R. Wick

Lung carcinoma to metatarsal - contributed by Dr. Mark R. Wick

Lung carcinoma metastasis


Prostate adenocarcinoma - contributed by Dr. Mark R. Wick

Prostate carcinoma - osteoblastic features

Thyroid carcinoma - contributed by Dr. Mark R. Wick

Thyroid carcinoma

Case Reports
Treatment
  • Radiation therapy for pain relief and to prevent fracture of weight bearing bones
Gross Images
Images hosted on PathOut server:

Lung carcinoma in humeral head - contributed by Dr. Mark R. Wick

Lung squamous cell carcinoma - contributed by Dr. Mark R. Wick

Micro Images
Images hosted on PathOut server:

Lung carcinoma to metatarsal - contributed by Dr. Mark R. Wick

Lung carcinoma to metatarsal - contributed by Dr. Mark R. Wick

Lung - metastatic carcinoma

Lung carcinoma to metatarsal TTF1 - contributed by Dr. Mark R. Wick

Lung - metastatic carcinoma BerEp4


Prostate adenocarcinoma - contributed by Dr. Mark R. Wick

Prostate - metastatic carcinoma

Renal cell carcinoma - contributed by Dr. Mark R. Wick

Thyroid - metastatic carcinoma

Differential Diagnosis
  • Myeloma: negative isotope bone scan, monoclonal protein in serum or urine