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Bone chapter (nontumor and tumor)
Hematologic neoplasms
Myeloma of bone

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 August 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See variants below: indolentmultilobated nucleinonsecretoryosteoscleroticplasma cell leukemia (primary)smoldering

General
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Serum protein electrophoresis images
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Monoclonal gammopathy

Serum protein immunofixation images
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IgD lambda myeloma in 68 year old woman

Flow cytometry images
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Prominent monotypic pattern (in this case lambda, with minimal kappa)

Clinical description
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Prognosis
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Prognostic factors
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Treatment
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Case reports
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Xray description
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Radiology images
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Prominent skull defect

Skull xray - contributed by Dr. Mark R. Wick

Tibia xray - contributed by Dr. Mark R. Wick


Plasma cell myeloma

Solitary plasma cell myeloma

Gross description
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Gross images
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Vertebrae with myeloma lesions

Plasma cell myeloma

Micro description
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Micro images
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Bone marrow-low power

Bone marrow-high power


Bone marrow smear

Flame cell


Hemangioma-like

Plasma cells forming rosettes

Prominent kappa staining


Prominent lambda staining

Sarcoidosis and myeloma


Contributed by Dr. Mark R. Wick

Kappa light chain immunoglobulin - contributed by Dr. Mark R. Wick


With amyloid production - contributed by Dr. Mark R. Wick

Plasma cell myeloma

Virtual slides
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Myeloma

Peripheral blood images
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Plasma cell

Plasma cells with blastic features

Positive stains
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Negative stains
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Molecular description
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Differential diagnosis
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Indolent myeloma

General
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Multilobated nuclei

General
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Micro description
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Micro images
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Multilobated nuclei

Kappa light chain staining

Differential diagnosis
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Additional references
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Nonsecretory myeloma

General
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Osteosclerotic myeloma

General
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Plasma cell leukemia (primary)

General
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Diagnosis
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Micro description
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Smoldering myeloma

General
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End of Bone chapter (nontumor and tumor) > Hematologic neoplasms > Myeloma of bone


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