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Table of Contents
Definition / general | Radiology description | Treatment | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Myofibrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonemyofibrosarcoma.html. Accessed July 14th, 2017.
Definition / general
- Rare, women in 60s and 70s
- Distal femur, tibia and iliac bones
Radiology description
- Well demarcated lytic destructive lesions without periosteal reaction, may extend into soft tissue
Treatment
- Wide resection, may have distant metastases
Microscopic (histologic) description
- Mixture of cell-rich fascicular area and hypocellular fibrous area
- Fascicular area has interlacing fascicles and storiform areas of tumor cells with eosinophilic spindled and wavy cytoplasm and variable inflammatory cells
- Variable pleomorphism and large cells with hyperchromatic nuclei
- Hypocellular areas are collagenous, hyaline scar-like and rarely keloid-like, with focal coagulation necrosis
- Infiltrative growth at periphery
- Reactive bone but no malignant osteoid
Positive stains
Negative stains
- High molecular weight caldesmon
Differential diagnosis
- Fibrosarcoma: negative for muscle markers, no inflammatory infiltrate
- Inflammatory myofibroblastic tumor: no necrosis
- Leiomyosarcoma: h-caldesmon+
- MFH of bone: more prominent anaplasia, multinucleated giant cells
Additional references
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