Bone & joints
Other tumors

Topic Completed: 1 June 2005

Revised: 3 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed search: myofibrosarcoma

Nat Pernick, M.D.
Page views in 2019: 553
Page views in 2020 to date: 487
Cite this page: Pernick N Myofibrosarcoma. website. Accessed October 20th, 2020.
Definition / general
  • Rare, women in 60s and 70s
  • Distal femur, tibia and iliac bones
Radiology description
  • Well demarcated lytic destructive lesions without periosteal reaction, may extend into soft tissue
  • Wide resection, may have distant metastases
Microscopic (histologic) description
  • Mixture of cell-rich fascicular area and hypocellular fibrous area
  • Fascicular area has interlacing fascicles and storiform areas of tumor cells with eosinophilic spindled and wavy cytoplasm and variable inflammatory cells
  • Variable pleomorphism and large cells with hyperchromatic nuclei
  • Hypocellular areas are collagenous, hyaline scar-like and rarely keloid-like, with focal coagulation necrosis
  • Infiltrative growth at periphery
  • Reactive bone but no malignant osteoid
Negative stains
Differential diagnosis
Additional references
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