Other tumors of bone

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: myofibrosarcoma

Cite this page: Myofibrosarcoma. website. Accessed October 18th, 2018.
Definition / general
  • Rare, women in 60s and 70s
  • Distal femur, tibia and iliac bones
Radiology description
  • Well demarcated lytic destructive lesions without periosteal reaction, may extend into soft tissue
  • Wide resection, may have distant metastases
Microscopic (histologic) description
  • Mixture of cell-rich fascicular area and hypocellular fibrous area
  • Fascicular area has interlacing fascicles and storiform areas of tumor cells with eosinophilic spindled and wavy cytoplasm and variable inflammatory cells
  • Variable pleomorphism and large cells with hyperchromatic nuclei
  • Hypocellular areas are collagenous, hyaline scar-like and rarely keloid-like, with focal coagulation necrosis
  • Infiltrative growth at periphery
  • Reactive bone but no malignant osteoid
Negative stains
Differential diagnosis
Additional references