Bone
Fibrous and Fibroosseous tumors of bone
Ossifying fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 October 2016, last major update November 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Ossifying fibroma[title]
Cite this page: Ossifying fibroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneossifyingfibroma.html. Accessed December 9th, 2016.
Definition / General
  • Benign neoplasm, affects ages 3 months to 70 years
  • Some are indolent; some growth rapidly
  • Sites: craniofacial skeleton (maxilla, mandible, paranasal sinuses); psammomatoid tumors usually don’t affect the jaw
  • Incidental or symptoms of facial enlargement, nasal obstruction, pain, proptosis
Case Reports
Treatment
  • Excision of small lesions, wide excision of large or rapidly growing lesions
  • 30-60% recur
  • No malignant transformation
Gross Description
  • Discrete mass that is well delineated from surrounding bone, no encapsulation, tan-white, rubbery cut surface, firm to gritty
Micro Description
  • Central lesion of bone with variable fibrous proliferation of round, polyhedral or spindly cells and calcifications
  • Trabecular and psammomatoid patterns, myxomatous matrix
  • Occasional osteoclast-like giant cells
  • Psammomatoid: numerous small, round ossicles or psammomatoid bodies embedded in cellular fibrous stroma; ossicles present within bony trabeculae and cellular stroma
Micro Images

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MRI, gross, H&E

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Psammomatoid: Xray, H&E

Differential Diagnosis
  • Central cementifying fibroma: women, typically involves jaw, cementicles related to dental cementum