Fibrous and fibroosseous tumors of bone
Ossifying fibroma

Topic Completed: 1 November 2014

Revised: 5 July 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Ossifying fibroma[title]

Nat Pernick, M.D.
Page views in 2019: 13,127
Page views in 2020 to date: 1,895
Cite this page: Pernick N. Ossifying fibroma. website. Accessed February 24th, 2020.
Definition / general
  • Benign neoplasm, affects ages 3 months to 70 years
  • Some are indolent; some growth rapidly
  • Sites: craniofacial skeleton (maxilla, mandible, paranasal sinuses); psammomatoid tumors usually don’t affect the jaw
  • Incidental or symptoms of facial enlargement, nasal obstruction, pain, proptosis
Case reports
  • Excision of small lesions, wide excision of large or rapidly growing lesions
  • 30-60% recur
  • No malignant transformation
Gross description
  • Discrete mass that is well delineated from surrounding bone, no encapsulation, tan-white, rubbery cut surface, firm to gritty
Microscopic (histologic) description
  • Central lesion of bone with variable fibrous proliferation of round, polyhedral or spindly cells and calcifications
  • Trabecular and psammomatoid patterns, myxomatous matrix
  • Occasional osteoclast-like giant cells
  • Psammomatoid: numerous small, round ossicles or psammomatoid bodies embedded in cellular fibrous stroma; ossicles present within bony trabeculae and cellular stroma
Microscopic (histologic) images

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MRI, gross, H&E

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Psammomatoid: Xray, H&E

Differential diagnosis
  • Central cementifying fibroma: women, typically involves jaw, cementicles related to dental cementum
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