Non-neoplastic or metabolic disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 October 2016, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Osteopoikilosis[title]
Cite this page: Osteopoikilosis. website. Accessed March 20th, 2018.
Definition / general
  • Usually autosomal dominant with high penetrance
  • No symptoms, no abnormal labs
  • Associated with osteosarcoma in affected bone, scleroderma, other conditions
Radiology description
  • Multiple sclerotic, round lesions of variable size in cancellous bone near joint surfaces
Microscopic (histologic) description
  • Resembles bone island