Bone
Osteosarcoma
Pagets disease associated osteosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Paget disease associated osteosarcoma
Cite this page: Pagets disease associated osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonepagetosteo.html. Accessed December 3rd, 2016.
Definition / General
  • Usually associated with polyostotic Paget disease
  • Multicentric tumors associated with increasing localized pain
  • Much older age than conventional osteosarcoma
  • Very poor prognosis, with death due to pulmonary metastasis or local extension
  • Sites: pelvis, humerus, femur, tibia, skull
Radiology Description
  • Paget disease and destruction
Radiology Images

Images hosted on Pathout server:

CT scan - contributed by Dr. Mark R. Wick

Xray - contributed by Dr. Mark R. Wick

Gross Images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Micro Description
  • High grade sarcoma (osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma) with osteoclasts and atypical osteoblasts
Micro Images

Images hosted on Pathout server:
Missing Image

Osteosarcoma arising in Paget disease

Paget disease of bone with secondary osteosarcoma - contributed by Dr. Mark R. Wick



Images hosted on other servers:
Missing Image

High grade sarcoma

Additional References