Bone
Osteosarcoma
Paget disease associated osteosarcoma


Topic Completed: 1 August 2013

Revised: 10 July 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Paget disease associated osteosarcoma

Nat Pernick, M.D.
Page views in 2018: 447
Page views in 2019 to date: 344
Cite this page: Pernick N. Paget disease associated osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonepagetosteo.html. Accessed August 20th, 2019.
Definition / general
  • Usually associated with polyostotic Paget disease
  • Multicentric tumors associated with increasing localized pain
  • Much older age than conventional osteosarcoma
  • Very poor prognosis, with death due to pulmonary metastasis or local extension
  • Sites: pelvis, humerus, femur, tibia, skull
Radiology description
  • Paget disease and destruction
Radiology images

Contributed by Dr. Mark R. Wick

CT scan

Xray

Gross images

Contributed by Dr. Mark R. Wick
Microscopic (histologic) description
  • High grade sarcoma (osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma) with osteoclasts and atypical osteoblasts
Microscopic (histologic) images

AFIP images
Missing Image

Osteosarcoma arising in Paget disease


Contributed by Dr. Mark R. Wick

Paget disease of bone with secondary osteosarcoma

Additional references
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