Bone & joints
Paget disease associated osteosarcoma

Topic Completed: 1 August 2013

Minor changes: 10 July 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Paget disease associated osteosarcoma

Nat Pernick, M.D.
Page views in 2019: 549
Page views in 2020 to date: 313
Cite this page: Pernick N. Paget disease associated osteosarcoma. website. Accessed August 14th, 2020.
Definition / general
  • Usually associated with polyostotic Paget disease
  • Multicentric tumors associated with increasing localized pain
  • Much older age than conventional osteosarcoma
  • Very poor prognosis, with death due to pulmonary metastasis or local extension
  • Sites: pelvis, humerus, femur, tibia, skull
Radiology description
  • Paget disease and destruction
Radiology images

Contributed by Dr. Mark R. Wick

CT scan


Gross images

Contributed by Dr. Mark R. Wick
Microscopic (histologic) description
  • High grade sarcoma (osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma) with osteoclasts and atypical osteoblasts
Microscopic (histologic) images

AFIP images
Missing Image

Osteosarcoma arising in Paget disease

Contributed by Dr. Mark R. Wick

Paget disease of bone with secondary osteosarcoma

Additional references
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