Bone
Osteosarcoma - variants
Periosteal osteosarcoma


Topic Completed: 1 November 2016

Revised: 10 July 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed search: periosteal [title] osteosarcoma

Nat Pernick, M.D.
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Page views in 2019 to date: 2,042
Cite this page: Pernick N. Periosteal osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneperiostealosteo.html. Accessed December 10th, 2019.
Definition / general
  • < 2% of all osteosarcomas
  • Same age as conventional osteosarcoma, slight female predominance
  • Related to periosteal chondrosarcoma
  • Sites: usually diaphysis of proximal tibia or femur
Radiology description
  • Small lucent lesions on bone surface with bone spicules perpendicular to shaft and penetrating soft tissues
  • No medullary involvement (by definition)
  • Good prognosis (better than high grade osteosarcoma, poorer than parosteal osteosarcoma or juxtacortical chondrosarcoma), with high local recurrence rate and 15% metastatic rate
Radiology images

AFIP images

Slight cortical thickening


Contributed by Dr. Mark R. Wick

Femur diaphyseal xray

Xray

Case reports
Gross description
  • Grows on surface of long bones
  • Limited to cortex with only rare medullary invasion
Gross images

AFIP images

Cross section


Contributed by Dr. Mark R. Wick

Femur

Microscopic (histologic) description
  • Intermediate to high grade osteosarcoma with prominent cartilaginous component
  • Cartilage in lobules with peripheral spindling and central bone formation
  • Malignant osteoid / bone is present, but may be focal
Microscopic (histologic) images

AFIP images

Malignant cartilage

Neoplastic osteoid

Spiculation of bone


Contributed by Dr. Mark R. Wick



Images hosted on other servers:

Xray, gross, H&E

Molecular / cytogenetics description
  • Usually diploid
Differential diagnosis
  • Juxtacortical chondrosarcoma: lobules of malignant cartilage with calcification and surface endochondral ossification; no malignant osteoid
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