Bone
Non-neoplastic or metabolic disease
SAPHO syndrome



Topic Completed: 01 July 2013

Revised: 27 December 2018

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PubMed Search: SAPHO syndrome[title]
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Cite this page: Pernick N SAPHO syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonesapho.html. Accessed January 21st, 2019.
Definition / general
  • Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis
  • Variable and nonspecific histologic findings
  • Often peculiar bone lesions of anterior chest wall and pustular dermatoses
  • Mean age 35 years, range 5 - 63 years
Microscopic (histologic) description
  • Early lesions resemble bacterial osteomyelitis with acute inflammation, edema, prominent periosteal bone formation
  • Late lesions have markedly sclerotic bony trabeculae with prominent marrow fibrosis and mild chronic inflammation
Additional references