Non-neoplastic or metabolic disease
SAPHO syndrome

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 October 2016, last major update July 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: SAPHO syndrome[title]
Cite this page: SAPHO syndrome. website. Accessed October 17th, 2018.
Definition / general
  • Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis
  • Variable and nonspecific histologic findings
  • Often peculiar bone lesions of anterior chest wall and pustular dermatoses
  • Mean age 35 years, range 5 - 63 years
Microscopic (histologic) description
  • Early lesions resemble bacterial osteomyelitis with acute inflammation, edema, prominent periosteal bone formation
  • Late lesions have markedly sclerotic bony trabeculae with prominent marrow fibrosis and mild chronic inflammation
Additional references