Bone
Other tumors of bone
Sinus histiocytosis with massive lymphadenopathy



Topic Completed: 1 June 2005

Revised: 4 January 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed search: sinus histiocytosis with massive lymphadenopathy [title]


Nat Pernick, M.D.
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Cite this page: Pernick N Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonesinushistio.html. Accessed December 5th, 2019.
Definition / general
  • Also called Rosai-Dorfman disease
  • Rare; unknown cause
  • Skeleton is fifth most common site of extranodal involvement
Radiology images

Skull CT scan

Microscopic (histologic) description
  • Fibrosis, polyclonal plasma cells, lymphocytes, histiocytes, lymphocytophagocytosis by histiocytes
Microscopic (histologic) images

Large, foamy histiocytes

Positive stains
  • S100 (histiocytes)
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