Sinus histiocytosis with massive lymphadenopathy

Bone
Other tumors of bone
Sinus histiocytosis with massive lymphadenopathy

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: sinus histiocytosis with massive lymphadenopathy [title]

Table of Contents

Definition / general | Radiology images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains

Cite this page: Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonesinushistio.html. Accessed July 14th, 2017.

Definition / general

Also called Rosai-Dorfman disease
Rare; unknown cause
Skeleton is fifth most common site of extranodal involvement

Radiology images

Images hosted on PathOut server:

Skull CT scan

Microscopic (histologic) description

Fibrosis, polyclonal plasma cells, lymphocytes, histiocytes, lymphocytophagocytosis by histiocytes

Microscopic (histologic) images

Images hosted on PathOut server:

Large, foamy histiocytes

Positive stains

S100 (histiocytes)