Other tumors of bone
Sinus histiocytosis with massive lymphadenopathy

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: sinus histiocytosis with massive lymphadenopathy [title]

Cite this page: Sinus histiocytosis with massive lymphadenopathy. website. Accessed October 21st, 2018.
Definition / general
  • Also called Rosai-Dorfman disease
  • Rare; unknown cause
  • Skeleton is fifth most common site of extranodal involvement
Radiology images
Images hosted on PathOut server:

Skull CT scan

Microscopic (histologic) description
  • Fibrosis, polyclonal plasma cells, lymphocytes, histiocytes, lymphocytophagocytosis by histiocytes
Microscopic (histologic) images
Images hosted on PathOut server:

Large, foamy histiocytes

Positive stains
  • S100 (histiocytes)