Bone
Osteosarcoma
Small cell osteosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update November 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Small cell osteosarcoma
Cite this page: Small cell osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonesmallcellosteo.html. Accessed December 3rd, 2016.
Definition / General
  • Very rare
  • Poor prognosis
Micro Description
  • Diffuse growth of small, uniform, round/spindle tumor cells, focally produces malignant osteoid, occasionally mixed with cartilage
Micro Images

Images hosted on Pathout server:

Small osteoblasts with indistinct cytoplasm

Lymphoma-like pattern

Small foci of osteoid

Foot - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Positive Stains
Electron Microscopy Description
  • High N/C ratio, poorly differentiated cytoplasm, numerous free ribosomes and mitochondria, small junctions, envelopment of individual and groups of cells by matrix (Hum Pathol 1991;22:267)
Differential Diagnosis
Additional References