Small cell osteosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update November 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Small cell osteosarcoma
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Cite this page: Small cell osteosarcoma. website. Accessed December 18th, 2018.
Definition / general
  • Very rare
  • Poor prognosis
Microscopic (histologic) description
  • Diffuse growth of small, uniform, round/spindle tumor cells, focally produces malignant osteoid, occasionally mixed with cartilage
Microscopic (histologic) images

Images hosted on Pathout server:

Small osteoblasts with indistinct cytoplasm

Lymphoma-like pattern

Small foci of osteoid

Foot - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Positive stains
Electron microscopy description
  • High N/C ratio, poorly differentiated cytoplasm, numerous free ribosomes and mitochondria, small junctions, envelopment of individual and groups of cells by matrix (Hum Pathol 1991;22:267)
Differential diagnosis
Additional references