Reviewers: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 16 March 2011, last major update March 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Infrequent (3-5%) variant of myeloma
● Single bone lesion with monoclonal plasma cell infiltrate
● No other lytic bone lesions
● No plasma cell infiltrates in random bone marrow biopsies
● Most commonly involves bones with active hematopoiesis – vertebrae, ribs, skull, pelvis, femur
● Rarely involves lymph nodes or peripheral blood
● Causes local bony destruction, pathologic bone fractures at same sites as myeloma
● No anemia, hypercalcemia or renal failure
● Usually progresses to myeloma, but may take 10-20 years
● Expansion of a single clone of immunoglobulin secreting plasma cells; increase in serum levels of single homogeneous immunoglobulin (monoclonal spike on serum electrophoresis)
● 36 year old man with tumor containing anaplastic cytology (Arch Pathol Lab Med 2004;128:237)
Plasmacytoma of rib
● Monoclonal plasma cell infiltrate
End of Bone > Hematologic neoplasms > Solitary plasmacytoma
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