Bone
Miscellaneous
Staging - Myeloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: staging [title] "myeloma"

Cite this page: Staging - Myeloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonestagingmyeloma.html. Accessed December 3rd, 2016.
Definition / General
International staging system
  • Stage I: serum beta2-microglobulin < 3.5 mg/L and serum albumin 3.5 g/dL or more
  • Stage II: not stage I or III Consists of either serum beta2-microglobulin < 3.5 mg/L but serum albumin < 3.5 g/dL or serum beta2-microglobulin 3.5 to < 5.5 mg/L irrespective of the serum albumin level
  • Stage III: serum beta2-microglobulin 5.5 mg/L or more

Durie-Salmon staging system
  • Stage I: hemogloblin > 10.0 g/dL, serum calcium ≤ 12 mg/dL, normal bone xrays or a solitary bone lesion, IgG < 5 g/dL, IgA < 3 g/dL and urine M protein < 4g/24 hours
  • Stage II: not stage I or III
  • Stage III: one or more of the following: hemoglobin < 8.5 g/dL, serum calcium > 12 mg/dL, advanced lytic bone lesions, IgG > 7 g/dL, IgA > 5 g/dL or urine M protein > 12 g/24 hours
    • Note: patients are further subclassified per stage grouping as either (A) serum creatinine < 2.0 mg/dL or (B) serum creatinine ≥ 2.0 mg/dL
Diagrams / Tables
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Table 2: New International Staging System