Other tumors of bone
Subungual keratoacanthoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: Subungual keratoacanthoma

Cite this page: Subungual keratoacanthoma. website. Accessed December 15th, 2018.
Definition / general
  • Rare; well circumscribed nail bed lesion producing lytic defects in underlying bone
  • Rapidly progressive
  • Benign; excision is curative
Radiology description
  • Well defined defect in bone
Microscopic (histologic) description
  • Proliferation of squamous cells with abundant pink cytoplasm and marked keratinization, resembling cutaneous lesion
Differential diagnosis
  • Squamous cell carcinoma: usually a chronic problem, tends to permeate bone