Other tumors of bone
Subungual keratoacanthoma

Topic Completed: 1 June 2005

Revised: 4 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed search: Subungual keratoacanthoma

Nat Pernick, M.D.
Page views in 2019: 298
Page views in 2020 to date: 93
Cite this page: Pernick N Subungual keratoacanthoma. website. Accessed June 7th, 2020.
Definition / general
  • Rare; well circumscribed nail bed lesion producing lytic defects in underlying bone
  • Rapidly progressive
  • Benign; excision is curative
Radiology description
  • Well defined defect in bone
Microscopic (histologic) description
  • Proliferation of squamous cells with abundant pink cytoplasm and marked keratinization, resembling cutaneous lesion
Differential diagnosis
  • Squamous cell carcinoma: usually a chronic problem, tends to permeate bone
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