Reviewers: Dariusz Borys, M.D. (see Reviewers page)
Revised: 16 August 2013, last major update June 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Caused by Treponema pallidum and T. pertenue (yaws)
● Bone involvement more common in congenital syphilis (Int J STD AIDS 1992;3:161); appears at 5th month of gestation in areas of active endochondral ossification (osteochondritis) and periosteum
● Acquired syphilis involves bone in tertiary phase, usually nose, palate, skull, tibia, vertebrae, hands/feet
● Reactive periosteal bone deposition (“saber shin” of tibia)
● Bone destruction and production
● Necrotic, well-defined bone defects of cortex and periosteum surrounded by sclerotic bone
● Edematous granulation tissue, plasma cells, granulomas, necrotic bone and new bone production
Secondary syphilis - contributed by Dr. Mark R. Wick
● Special silver stains
End of Bone > Osteomyelitis > Syphilitic osteomyelitis
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