Bone
Osteosarcoma
Telangiectatic osteosarcoma

Author: David L. Stockman, M.D. (see Authors page)

Revised: 16 August 2018, last major update April 2016

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Bone telangiectatic osteosarcoma
Cite this page: Stockman, D.L. Telangiectatic osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonetelangosteo.html. Accessed December 11th, 2018.
Definition / general
  • 3% of osteosarcomas
  • High grade variant of osteosarcoma showing significant cystic change with hemorrhage and necrosis
  • Rapid growth of tumor causes tumor necrosis, hemorrhage and cystic cavitation
  • Associated with pathologic fractures, dull pain and swelling for a few months duration
Radiology description
  • Lesions are extremely lytic and expansile, may suggest aneurysmal bone cyst or hematoma
  • Magnetic resonance imaging may show fluid fluid levels, again correlating with aneurysmal bone cyst
Treatment
  • Resection and neoadjuvant therapy; protocols same as conventional osteosarcoma
Radiology images

Images hosted on PathOut server:

AFIP images:

Proximal fibula


Contributed by Dr. Mark R. Wick:

Xray

Gross description
  • Lobulated expansile tumor occurring predominantly in metaphyseal area with cystic spaces filled with blood and necrosis
Gross images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Various images

Proximal tibia



Images hosted on other servers:

Tumor with blood filled cavity

Microscopic (histologic) description
  • Prominent blood filled cysts separated by septa containing malignant hypercellular and anaplastic stroma
  • Demonstrates very little osteoid production
  • May form eccentric or circumferential soft tissue component that displaces periosteum peripherally
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Telangiectatic and small cell

Various images


Various images



AFIP images:

Coronal section

Sparse solid areas

Markedly abnormal nuclei

Delicate, calcified osteoid



Images hosted on other servers:

Blood filled cystic spaces with malignant stroma

Differential diagnosis