Bone
Osteosarcoma
Telangiectatic osteosarcoma


Topic Completed: 1 April 2016

Revised: 10 July 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Bone telangiectatic osteosarcoma

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Cite this page: Stockman DL. Telangiectatic osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonetelangosteo.html. Accessed November 15th, 2019.
Definition / general
  • 3% of osteosarcomas
  • High grade variant of osteosarcoma showing significant cystic change with hemorrhage and necrosis
  • Rapid growth of tumor causes tumor necrosis, hemorrhage and cystic cavitation
  • Associated with pathologic fractures, dull pain and swelling for a few months duration
Radiology description
  • Lesions are extremely lytic and expansile, may suggest aneurysmal bone cyst or hematoma
  • Magnetic resonance imaging may show fluid fluid levels, again correlating with aneurysmal bone cyst
Treatment
  • Resection and neoadjuvant therapy; protocols same as conventional osteosarcoma
Radiology images

AFIP images

Proximal fibula


Contributed by Dr. Mark R. Wick

Xray

Gross description
  • Lobulated expansile tumor occurring predominantly in metaphyseal area with cystic spaces filled with blood and necrosis
Gross images

Contributed by Dr. Mark R. Wick

Various images

Proximal tibia

Microscopic (histologic) description
  • Prominent blood filled cysts separated by septa containing malignant hypercellular and anaplastic stroma
  • Demonstrates very little osteoid production
  • May form eccentric or circumferential soft tissue component that displaces periosteum peripherally
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Telangiectatic and small cell

Various images


Various images



AFIP images

Coronal section

Sparse solid areas

Markedly abnormal nuclei

Delicate, calcified osteoid

Differential diagnosis
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