Bone
Osteosarcoma
Telangiectatic osteosarcoma

Author: David L. Stockman, M.D. (see Authors page)

Revised: 14 April 2016, last major update April 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Bone telangiectatic osteosarcoma
Cite this page: Telangiectatic osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonetelangosteo.html. Accessed December 9th, 2016.
Definition / General
  • 3% of osteosarcomas
  • High grade variant of osteosarcoma showing significant cystic change with hemorrhage and necrosis
  • Rapid growth of tumor causes tumor necrosis, hemorrhage and cystic cavitation
  • Associated with pathologic fractures, dull pain and swelling for a few months duration
Radiology Description
  • Lesions are extremely lytic and expansile, may suggest aneurysmal bone cyst or hematoma
  • Magnetic resonance imaging may show fluid fluid levels, again correlating with aneurysmal bone cyst
Treatment
  • Resection and neoadjuvant therapy; protocols same as conventional osteosarcoma
Radiology Images

Proximal fibula

Xray - contributed by Dr. Mark R. Wick

Gross Description
  • Lobulated expansile tumor occurring predominantly in metaphyseal area with cystic spaces filled with blood and necrosis
Gross Images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Proximal tibia - contributed by Dr. Mark R. Wick



Images hosted on other servers:

Tumor with blood filled cavity

Micro Description
  • Prominent blood filled cysts separated by septa containing malignant hypercellular and anaplastic stroma
  • Demonstrates very little osteoid production
  • May form eccentric or circumferential soft tissue component that displaces periosteum peripherally
Micro Images

Images hosted on Pathout server:

Telangiectatic and small cell - contributed by Dr. Mark R. Wick


Contributed by Dr. Mark R. Wick


Contributed by Dr. Mark R. Wick


Coronal section

Sparse solid areas

Markedly abnormal nuclei

Delicate, calcified osteoid



Images hosted on other servers:

Blood filled cystic spaces with malignant stroma



Images hosted on Nature.com:

Large cystic spaces

Differential Diagnosis