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Bone chapter (nontumor and tumor)
Osteosarcoma variants
Well differentiated intramedullary osteosarcoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 12 August 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Xray description
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Radiology images
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Distal femoral metaphysis

Part of cortex destroyed

Metaphysis and epiphysis of tibia

Gross description
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Gross images
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Proximal portion of humerus

Medullary cavity

Micro description
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Micro images
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Markedly pleomorphic osteoblasts

Focal osteoid formation

Neoplastic osteoblasts

Heavily calcified osteoid

Conventional intramedullary osteosarcoma


Low grade cartilaginous differentiation

"Herringbone" pattern

Spindled, fibroblast-like tumor cells

Minimal osteoid deposition

Dense osteoid surrounds blood vessel


Treated conventional osteosarcoma

Amorphous deposits of osteoid in stroma

Mature-appearing bone

Broad trabeculae of bone

Molecular description
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Differential diagnosis
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End of Bone chapter (nontumor and tumor) > Osteosarcoma variants > Well differentiated intramedullary osteosarcoma


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