Home Chapter Home Jobs Conferences Fellowships Books

Advertisement

Breast-nonmalignant

Benign tumors / changes

Hemangiopericytoma of breast

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 7 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

Definition

=========================================================================

● Rare, low grade malignant tumor with circumscribed area of bland spindled cells with branching and staghorn vessels

Terminology

=========================================================================

●

Epidemiology

=========================================================================

● Very rare

● Usually women 33-67 years

Sites

=========================================================================

●

Etiology

=========================================================================

●

Clinical features

=========================================================================

● Painless, nontender nodules

Prognostic factors

=========================================================================

●

Case reports

=========================================================================

● 66 year old woman (Arch Gynecol Obstet 2008;277:357)

● Metastases and death due to disease (Arch Gynecol Obstet 2009;280:491)

Treatment

=========================================================================

● Complete local excision with breast preservation

● Mastectomy may be necessary for large lesions (Mod Pathol 1988;1:98)

Clinical images

=========================================================================

●

Gross description (Macroscopy)

=========================================================================

● Mean 6-9 cm, well circumscribed

Gross images

=========================================================================

Micro description (Histopathology)

=========================================================================

● Thin walled, staghorn-type vessels separated by polygonal cells with indistinct margins, pale cytoplasm and small round/oval nuclei

Micro images

=========================================================================

Thin walled staghorn-type vessels separated           Reticulin stain outlines each cell

by polygonal cells with indistinct margins,

pale cytoplasm and small round/oval nuclei

Sinonasal tumor                                       CNS tumor: H&E (2) and diffuse reticulin staining

Drawings

=========================================================================

Virtual Slides

=========================================================================

Videos

=========================================================================

Cytology description

=========================================================================

● Cellular; single and tightly packed clusters of oval to spindled cells aggregating around branched capillaries

● Nuclei are uniform, oval with finely granular chromatin and indistinct nucleoli; usually basement membrane material

● No mitotic figures, no necrosis (Cancer 1999;87:190)

Positive stains

=========================================================================

● Reticulin outlines each cell

Negative stains

=========================================================================

●

Electron microscopy descriptions

=========================================================================

● Pericytes associated with vessels (Am J Surg Pathol 1981;5:745)

Electron microscopy images

=========================================================================

Molecular / cytogenetics description

=========================================================================

●

Molecular / cytogenetics images

=========================================================================

Differential Diagnosis

=========================================================================

●

Additional references

=========================================================================

●

End of Breast-nonmalignant > Benign tumors / changes > Hemangiopericytoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc.  Information from third parties may also be protected by copyright.  Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).