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Breast-nonmalignant

Benign tumors / changes

Hemangiopericytoma of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 7 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Rare, low grade malignant tumor with circumscribed area of bland spindled cells with branching and staghorn vessels

 

Terminology

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Epidemiology

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● Very rare

● Usually women 33-67 years

 

Sites

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Etiology

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Clinical features

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● Painless, nontender nodules

 

Prognostic factors

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Case reports

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● 66 year old woman (Arch Gynecol Obstet 2008;277:357)

● Metastases and death due to disease (Arch Gynecol Obstet 2009;280:491)

 

Treatment

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● Complete local excision with breast preservation

● Mastectomy may be necessary for large lesions (Mod Pathol 1988;1:98)

 

Clinical images

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Gross description (Macroscopy)

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● Mean 6-9 cm, well circumscribed

 

Gross images

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Micro description (Histopathology)

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● Thin walled, staghorn-type vessels separated by polygonal cells with indistinct margins, pale cytoplasm and small round/oval nuclei   

 

Micro images

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Thin walled staghorn-type vessels separated           Reticulin stain outlines each cell

by polygonal cells with indistinct margins,

pale cytoplasm and small round/oval nuclei

 

 

            

Sinonasal tumor                                       CNS tumor: H&E (2) and diffuse reticulin staining

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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● Cellular; single and tightly packed clusters of oval to spindled cells aggregating around branched capillaries

● Nuclei are uniform, oval with finely granular chromatin and indistinct nucleoli; usually basement membrane material

● No mitotic figures, no necrosis (Cancer 1999;87:190)


Positive stains

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● Reticulin outlines each cell

 

Negative stains

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Electron microscopy descriptions

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● Pericytes associated with vessels (Am J Surg Pathol 1981;5:745)

 

Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Hemangiopericytoma

 

 

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