Home Chapter Home Jobs Conferences Fellowships Books
Advertisement
Breast-nonmalignant
Inflammatory / infectious
Tuberculosis
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 30 September 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
=========================================================================
●
Terminology
=========================================================================
● Also called tuberculous mastitis
Epidemiology
=========================================================================
● Rare in Western countries, but more common in India (The Internet Journal of Tropical Medicine 2005;2(2))
Sites
=========================================================================
●
Etiology
=========================================================================
●
Clinical features
=========================================================================
● May present with abscess, fistula or mass (Trans R Soc Trop Med Hyg 2009;103:559)
● Usually unilateral without pulmonary involvement (ANZ J Surg 2006;76:234, Clinics (Sao Paulo) 2009;64:607)
● Acid-fast bacilli are usually not identified
● For breast cancer patients with granulomatous axillary lymphadenitis, PCR may be required to rule out TB in endemic regions (Pathol Res Pract. 2007;203:699)
Prognostic factors
=========================================================================
●
Case reports
=========================================================================
● 30 year old woman with costochondral junction TB presenting as breast mass (Cases J 2009 Sep 9;2:7039)
● 47 year old woman with coexisting ductal carcinoma (World J Surg Oncol 2008;6:29)
● 54 year old woman with Mycobacterium abscessus, a particularly pathogenic strain (J Plast Reconstr Aesthet Surg 2010;63:e397)
● 73 year old woman with TB mimicking breast cancer (J Med Case Reports 2008;2:34)
Treatment
=========================================================================
● Antibiotics (eMedicine); excision of mass may also be necessary (J Coll Physicians Surg Pak 2009;19:158)
Clinical images
=========================================================================
Resembles breast carcinoma Costochondral junction TB
Partially healed fistulas after Discoloration of overlying skin
Initiation of treatment and multiple sinuses
Gross description (Macroscopy)
=========================================================================
● Multiple sinuses or fistulas; may have focal discoloration or mass
Gross images
=========================================================================
Micro description (Histopathology)
=========================================================================
● Granulomas with Langhans giant cells and caseous necrosis (often)
Micro images
=========================================================================
Granulomatous inflammation of major Granulomatous inflammation
lactiferous duct with epithelial necrosis and Langhans giant cells
Granuloma with central necrosis and Suppurative granuloma
epithelioid histiocytes and inflammatory infiltrate
TB and infiltrating ductal carcinoma
Virtual Slides
=========================================================================
Videos
=========================================================================
Cytology description
=========================================================================
● Foamy histiocytes, neutrophils, necrotic debris
Cytology images
=========================================================================
●
Positive stains
=========================================================================
●
Negative stains
=========================================================================
●
Electron microscopy descriptions
=========================================================================
●
Electron microscopy images
=========================================================================
Molecular / cytogenetics description
=========================================================================
●
Molecular / cytogenetics images
=========================================================================
Differential Diagnosis
=========================================================================
● (link to topic)
Additional references
=========================================================================
●
End of Breast-nonmalignant > Inflammatory / infectious > Tuberculosis
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).