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General
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Clinical images
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Mammogram - courtesy of Dr. Mark R. Wick

Gross description
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Gross images
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Unusually large bisected tumor with central cavity with bosselated contour (AFIP)

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Intracystic nodule

Micro description
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Micro images
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Courtesy of Dr. Mark R. Wick

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Proliferation of epithelial and myoepithelial cells, Webpathology.com

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Myoepithelial cells

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Reactive for keratin and actin

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Various images

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Myoepithelial cells can be difficult to recognize

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Various images and stains

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With collagenous spherulosis



AFIP Images:

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Intraductal bands of pale myoepithelium separate adenomatous ductal epithelium

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Myoepithelial cells with clear cytoplasm crowd glandular epithelium and expand into stroma

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Overgrowth of myoepithelium in two nodules separated by stromal band

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Myoepithelial cells in small clusters have replaced most ductal elements

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Foci of glands with luminal secretions

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Isolated myoepithelial cells with clear vacuolated cytoplasm

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Transition between adenomatous and myomatous growth

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AE1+ glandular cells, (myoepothelial cells are negative)



Benign histology but malignant behavior:

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Benign appearing tumors that metastasized to lung

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Lung metastases with benign histology



Malignant histology:

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Mitotic activity

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Various images

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Keratin+ epithelium

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AE1-AE3, S100

Cytology description
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Cytology images
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Various images

Virtual Slides
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Adenomyoepithelioma

Positive stains
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Negative stains
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Electron microscopy descriptions
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Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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End of Breast - nonmalignant > Benign (usually) tumors / tumor like-changes > Adenomyoepithelioma



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