Fibrocystic changes
Adenomyoepithelial adenosis

Topic Completed: 1 November 2014

Minor changes: 20 October 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Adenomyoepithelial adenosis

Jaya Ruth Asirvatham, M.B.B.S.
Julie M. Jorns, M.D.
Page views in 2019: 3,356
Page views in 2020 to date: 3,262
Cite this page: Asirvatham JR, Jorns JM. Adenomyoepithelial adenosis. website. Accessed November 27th, 2020.
Definition / general
  • Uncommon variant of adenosis with proliferation of epithelial and myoepithelial cells
Clinical features
Radiology description
  • No specific features
  • May show focal asymmetry, irregular margins or microcalcification and mimic malignancy
Case reports
  • Excision recommended due to possibility of recurrence and association with malignancy
  • Best predictors of recurrence are initial incomplete excision and close margins
Radiology images

Images hosted on other servers:

Left breast

Hypoechoic mass

Irregular spiculated dense mass

Spiculated hypoechoic mass

Microscopic (histologic) description
  • Multiple foci of haphazardly arranged ducts with eosinophilic granular secretions
  • Lined by cuboidal to columnar cells surrounded by hyperplastic myoepithelial cells
  • Resembles microglandular adenosis but with larger and more irregularly shaped glands, taller lining epithelial cells with eosinophilic granular cytoplasm and bland basal nuclei
  • May show apocrine or squamous metaplasia (Breast Care (Basel) 2008;3:427)
  • May have mild nuclear atypia
  • Rare to no mitotic activity
Microscopic (histologic) images

Images hosted on other servers:

Adenomyoepithelial adenosis

Myoepithelial cells

AE1 / AE3


Positive stains
Differential diagnosis
Back to top
Image 01 Image 02