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Breast-nonmalignant
Adenosis
Adenomyoepithelial adenosis
Author: Nat Pernick, M.D.
Revised: 1 March 2010, last major update - March 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Uncommon variant of adenosis with prominent myoepithelial cells
Terminology
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● Also called apocrine adenosis or secretory adenosis (Stanford School of Medicine), although adenomyoepithelial adenosis has prominent myoepithelial cells in 1-3 layers
Epidemiology
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● Uncommon
Sites
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Etiology
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Clinical features
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● May be a precursor to adenomyoepithelioma (Am J Clin Pathol 1988;89:308, Virchows Arch A Pathol Anat Histopathol 1984;405:55)
Prognostic factors
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Case reports
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● Associated with adenocarcinoma (Pathol Int 1994;44:475)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Multiple foci of haphazardly arranged ducts with eosinophilic granular secretions
● Resembles microglandular adenosis but with larger and more irregularly shaped glands, taller lining epithelial cells with eosinophilic granular cytoplasm and bland basal nuclei
● Has identifiable myoepithelial cells with strikingly clear cytoplasm
● Infiltrative growth pattern
● May have mild atypia
● Often associated with adenomyoepithelioma
Micro images
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Large glands with open lumina S100 stains
and apocrine metaplasia myoepithelial cells
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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● Actin (myoepithelial cells)
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Adenosis > Adenomyoepithelial adenosis
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