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Breast-nonmalignant

Adenosis

Adenomyoepithelial adenosis

 

Author: Nat Pernick, M.D.

Revised: 3 October 2012, last major update - March 2010

Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

 

Definition

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● Uncommon variant of adenosis with prominent myoepithelial cells

 

Terminology

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● Also called apocrine adenosis or secretory adenosis (Stanford School of Medicine), although adenomyoepithelial adenosis has prominent myoepithelial cells in 1-3 layers

 

Epidemiology

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● Uncommon

 

Sites

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Etiology

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Clinical features

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● May be a precursor to adenomyoepithelioma (Am J Clin Pathol 1988;89:308, Virchows Arch A Pathol Anat Histopathol 1984;405:55)

 

Prognostic factors

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Case reports

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● Associated with adenocarcinoma (Pathol Int 1994;44:475)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Multiple foci of haphazardly arranged ducts with eosinophilic granular secretions

● Resembles microglandular adenosis but with larger and more irregularly shaped glands, taller lining epithelial cells with eosinophilic granular cytoplasm and bland basal nuclei

● Has identifiable myoepithelial cells with strikingly clear cytoplasm

● Infiltrative growth pattern

● May have mild atypia

● Often associated with adenomyoepithelioma


Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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● Actin (myoepithelial cells)

 

Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Adenosis > Adenomyoepithelial adenosis

 

 

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