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Breast-nonmalignant
Adenosis of breast - general
Editor: Hind Nassar, M.D., Johns Hopkins Medical Centers (see Reviewers page)
Revised: 29 July 2010, last major update July 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Any hyperplastic process (see subtypes below) primarily involving glands (i.e. an increased number of glandular components)
● Common, benign, often accompanied by fibrosis
Terminology
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Multiple types of adenosis are described:
● Simple adenosis
Epidemiology
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● Premenopausal: lesions with predominant epithelial component (proliferation of acini and ducts)
● Postmenopausal: lesions with more sclerosis (sclerosing adenosis)
Sites
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● Not specific
Etiology
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● Part of fibrocystic changes
Clinical features
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● Can present as a mass (tumor adenosis) or as calcifications on imaging
Prognostic factors
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● With some types (sclerosing adenosis), the risk of subsequent breast cancer is 1.5-2x higher
Treatment
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● Does not require treatment if there is no cytologic atypia
Micro description (Histopathology)
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See also separate topics for each subtype
● Apocrine adenosis: adenosis with predominant apocrine cytology
● Microglandular adenosis: proliferation of mammary glands with an infiltrative pattern
● Sclerosing adenosis: distortion of the lobule by the predominant proliferation of myoepithelial cells
● Simple adenosis: loosely structured proliferation of acinar or tubular structures, with epithelial and myoepithelial layers, surrounded by basement membrane
● Tubular adenosis: proliferation of ducts
Micro images
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Low power shows a somewhat Enlarged lobules
lobular architecture
Epithelial and myoepithelial cells Adenosis with columnar cell change
Various images
Reticulin stain demonstrates continuous basement membrane around glands (AFIP)
Differential Diagnosis
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● Invasive carcinoma: mainly an issue in cases of sclerosing, tubular and microglandular adenosis
End of Breast-nonmalignant > Adenosis of breast - general
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