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Breast-nonmalignant

Adenosis of breast - general

 

Editor: Hind Nassar, M.D., Johns Hopkins Medical Centers (see Reviewers page)

Revised: 4 October 2012, last major update July 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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Any hyperplastic process (see subtypes below) primarily involving glands (i.e. an increased number of glandular components)

Common, benign, often accompanied by fibrosis

 

Terminology

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Multiple types of adenosis are described:

Apocrine adenosis

Microglandular adenosis 

Sclerosing adenosis

● Simple adenosis

Tubular adenosis

 

Epidemiology

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● Premenopausal: lesions with predominant epithelial component (proliferation of acini and ducts)

● Postmenopausal: lesions with more sclerosis (sclerosing adenosis)

 

Sites

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● Not specific

 

Etiology

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● Part of fibrocystic changes

 

Clinical features

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● Can present as a mass (tumor adenosis) or as calcifications on imaging

 

Prognostic factors

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● With some types (sclerosing adenosis), the risk of subsequent breast cancer is 1.5-2x higher

  

Treatment

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● Does not require treatment if there is no cytologic atypia

 

Micro description (Histopathology)

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See also separate topics for each subtype

Apocrine adenosis: adenosis with predominant apocrine cytology

Microglandular adenosis: proliferation of mammary glands with an infiltrative pattern

Sclerosing adenosis: distortion of the lobule by the predominant proliferation of myoepithelial cells

Simple adenosis: loosely structured proliferation of acinar or tubular structures, with epithelial and myoepithelial layers, surrounded by basement membrane

Tubular adenosis: proliferation of ducts

 

Micro images

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                                                                en12.jpg (54219 bytes)

Low power shows a somewhat                                     Enlarged lobules

lobular architecture

 

 

en12.jpg (54219 bytes)                                                                  

Epithelial and myoepithelial cells                                   Adenosis with columnar cell change

 

 

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Various images

 

 

Reticulin stain demonstrates continuous basement membrane around glands (AFIP)

 

Differential Diagnosis

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Invasive carcinoma: mainly an issue in cases of sclerosing, tubular and microglandular adenosis

 

End of Breast-nonmalignant > Adenosis of breast - general

 

 

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