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General
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Terminology
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Epidemiology
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Etiology
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Clinical features
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Prognostic features
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Treatment
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Micro description
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Micro images
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AFIP Images:

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Cells don't stream and are haphazardly arranged in cellular bridges with mitotic activity (arrows), but secondary lumina are irregular

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Cells have uniform size and shape, small foci of necrosis and calficiation, but secondary lumina are irregular and more numerous at periphery

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Uniform cells but irregular secondary lumina

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Rounded secondary lumens and heterogenous cell population

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Ducts are lined by crowded, hyperplastic, tall columnar cells forming small papillae

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Papillary proliferation of multilayered epithelium involving only part of duct



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Courtesy of Dr. Mark R. Wick

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Irregular glandular spaces

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Enlarged, irregular, hyperchromatic nuclei

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Solid filling of a duct

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Atypical cells quite homogeneous

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Atypical ductal hyperplasia is present (arrows)

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Boxed area have less active-appearing nuclei

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Micropapillary and cribriform pattern

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Nuclei are crowded and hyperchromatic

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Similar architecture seen in DCIS

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Nuclei are crowded and overlapping

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Proliferating epithelium are rigid and "punched out"

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Nuclei are haphazardly arranged

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Cribriform type

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Micropapillary type

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Cribriform type, high power

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Cells are irregularly arranged

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Cell margins are indistinct

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Various images of ADH at core biopsy

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Usual ductal hyperplasia (CK903+) versus ADH (CK903-)

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ADH and subsequent invasive carcinoma

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Contributed by Dr. Marilin Rosa, University of Florida - ADH involving areas of sclerosing adenosis in complex sclerosing lesion

Virtual slides
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ALH and ADH involving a fibroadenoma

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ADH, papillary lesions

Cytology description
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Cytology images
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ADH

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Ductal lavage

Negative stains
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Differential diagnosis
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End of Breast - nonmalignant > Atypical hyperplasia > Atypical ductal hyperplasia (ADH)



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