Breast nonmalignant
Benign tumors

Topic Completed: 1 August 2015

Minor changes: 4 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Angiolipoma [title] breast

Monika Roychowdhury, M.D.
Page views in 2019: 2,129
Page views in 2020 to date: 961
Cite this page: Roychowdhury M. Angiolipoma. website. Accessed May 31st, 2020.
Definition / general
  • Nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi (essentially a lipoma with prominent vascular features)
  • Described by Bowen a century ago and established as a pathologic entity by Howard and Helwig in 1960 (Arch Dermatol 1960;82:924)
  • Usually subcutaneous nodules on extremities and trunks of young adults, rare in breast
  • When in breast, it develops in subcutaneous fat, just in front of the pectoral fascia muscle and not within the breast parenchyma itself
  • Unknown
Clinical features
  • Usually no pain, unlike angiolipoma elsewhere
  • Rarely exceeds 2 cm diameter
Radiology description
  • Mammography / Xray: no typical appearance, may appear as focal increased density or an ill defined mass / nodule
  • Ultrasound: well circumscribed hyperechoic mass without posterior enhancement
Prognostic factors
  • Not known to undergo malignant transformation
Case reports
  • Usually simple surgical excision is curative
  • Wide excision may be needed for infiltrative variant
Microscopic (histologic) description
  • Circumscribed mass composed of mature adipose tissue mixed with capillary sized interanastomosing vascular proliferation
  • Intraluminal fibrin thrombi are common
  • Periphery of the lesion has a tendency for higher vascular density
  • The World Health Organization (WHO) 2002 classification of tumors of soft tissue and bone subclassifies into low vascular density (low vascularity) and cellular (50% or more vascular tissue, 25 - 30% of lesions, Int J Surg Pathol 2011;19:35, Breast J 2002;8:182)
Microscopic (histologic) images

AFIP images:
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endothelial cells

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Soft tissue: mature adipose tissue and prominent vasculature

 Contributed by Dr. Mark R. Wick:
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Images hosted on other servers:
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Capillary vessels with microthrombi

Cytology description
  • Hypocellular, mature adipose tissue in hemorrhagic background
  • Rare, benign appearing spindled endothelial cells in clusters or strands resembling capillaries (Cancer 1999;87:359)
Positive stains
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