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Breast-nonmalignant
Angiolipoma of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 25 March 2010, last major update March 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi
Terminology
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Epidemiology
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Sites
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● Usually subcutaneous nodules on extremities and trunks of young adults, rare in breast
Etiology
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Clinical features
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● Usually NO pain, unlike these tumors elsewhere
Case reports
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● 55 year old man (Int J Surg Pathol 2009 Dec 24 [Epub ahead of print])
● 70 year old woman with breast mass (Radiology 2003;227:773)
● 75 year old woman with multiple bilateral tumors (Aust NZ J Surg 1982;52:614)
● Cellular angiolipomas (Breast J 2002;8:47, Mod Path 1993;6:497)
Treatment
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● Simple excision
Clinical images
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Gross description (Macroscopy)
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● Encapsulated yellow nodule(s) up to 2 cm
Gross images
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Micro description (Histopathology)
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● Well circumscribed lesion of mature adipose tissue and capillary sized vessels
● Hyaline thrombi in vessels
● Usually non-infiltrative
● May be cellular
● Adipose tissue component may be minimal
● No necrosis, no atypia, no hemorrhage, no mitotic figures
Micro images
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Mature adipose tissue and capillaries AFIP Fig 475: anastomosing capillaries
in fibrous stroma lined by inconspicuous endothelial cells
Site unknown - Mature adipose tissue and capillaries; Capillary proliferation between adipocytes
Soft tissue (AFIP): mature adipose tissue Mediastinal tumor
and prominent vasculature
Cellular angiolipoma (site unknown)
Other images: #1
Virtual Slides
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Videos
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Cytology description
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● Hypocellular, mature adipose tissue in hemorrhagic background
● Rare, benign appearing spindled endothelial cells in clusters or strands resembling capillaries (Cancer 1999;87:359)
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● (link to topic)
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Angiolipoma of breast
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