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Breast-nonmalignant

Benign tumors / changes

Angiolipoma of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 5 October 2012, last major update March 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi

 

Terminology

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Epidemiology

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Sites

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● Usually subcutaneous nodules on extremities and trunks of young adults, rare in breast

 

Etiology

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Clinical features

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● Usually NO pain, unlike these tumors elsewhere

 

Case reports

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● 55 year old man (Int J Surg Pathol 2009 Dec 24 [Epub ahead of print])

● 70 year old woman with breast mass (Radiology 2003;227:773)

● 75 year old woman with multiple bilateral tumors (Aust NZ J Surg 1982;52:614)

● Cellular angiolipomas (Breast J 2002;8:47, Mod Path 1993;6:497)

 

Treatment

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● Simple excision

 

Clinical images

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Gross description (Macroscopy)

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● Encapsulated yellow nodule(s) up to 2 cm

 

Gross images

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Micro description (Histopathology)

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● Well circumscribed lesion of mature adipose tissue and capillary sized vessels

● Hyaline thrombi in vessels

● Usually non-infiltrative

● May be cellular

● Adipose tissue component may be minimal

● No necrosis, no atypia, no hemorrhage, no mitotic figures

 

Micro images

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Mature adipose tissue and capillaries                        AFIP Fig 475: anastomosing capillaries

in fibrous stroma                                                              lined by inconspicuous endothelial cells

 


Site unknown: capillary proliferation between adipocytes

 

 

      

Soft tissue (AFIP): mature adipose tissue and prominent vasculature

 

Other images: #1

 

Virtual Slides

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Videos

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Cytology description

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● Hypocellular, mature adipose tissue in hemorrhagic background

● Rare, benign appearing spindled endothelial cells in clusters or strands resembling capillaries (Cancer 1999;87:359)

 

Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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● (link to topic)

 

Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Angiolipoma of breast

 

 

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