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Breast-nonmalignant

Benign tumors / changes

Benign stromal spindle cell tumors (BSSCT)

 

Reviewer: Nat Pernick, M.D.

Revised: 6 October 2012, last major update April 2010

Copyright: (c) 2010, PathologyOutlines.com, Inc.

 

Definition

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● Tumors composed of benign spindle cells, with variable lines of differentiation

● First described by Toker (Cancer 1981;48:1615)

● Terminology used in Tavassoli: Tumors of the Mammary Gland (AFIP Fascicle, 4th series, volume 10); 2009

           

Terminology

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Myofibroblastoma: BSSCT with predominant myofibroblastic differentiation

Spindle cell lipoma: BSSCT with predominant adipocytic component

Solitary fibrous tumor / hemangiopericytoma: BSSCT with predominant fibroblastic elements

 

Epidemiology

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Sites

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Etiology

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● Mesenchymal tumors composed of cells capable of various lines of differentiation, including fibroblasts, myofibroblasts, adipocytes and smooth muscle cells

● Histologic variations reflect the features seen in the four types of myofibroblasts: V-vimentin, VA-vimentin and actin, VAD-vimentin, actin and desmin and VADM-vimentin, actin, desmin and myosin (Am J Surg Pathol 1998;22:141)

 

Clinical features

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● Benign

 

Prognostic factors

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Case reports

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Treatment

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Clinical images

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Gross description (Macroscopy)

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● Solid, noncystic, well circumscribed

 

Gross images

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Micro description (Histopathology)

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Micro images

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Drawings

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Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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● Vimentin, CD34, bcl2, CD10, CD99, smooth muscle actin, desmin

 

Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Myoepithelial carcinoma, spindle cell subtype: nuclear atypia, mitotic figures, necrosis, keratin+

Myofibrosarcoma: mitotic figures and necrosis

Sarcomatoid carcinoma: may have hemangiopericytoma-like vascular pattern, but also nuclear atypia, frequent and atypical mitotic figures, necrosis

Spindle cell myoepithelioma: no collagen bundles, keratin+

 

Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Benign stromal spindle cell tumors

 

 

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