Home Chapter Home Jobs Conferences Fellowships Books
Advertisement
Breast-nonmalignant
Benign tumors / changes
Carney’s syndrome
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 6 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
=========================================================================
● Autosomal dominant syndrome of myxomas / myxoid lesions in skin, subcutis and breast (Am J Surg Pathol 1991;15:713)
● Also considered a familial multiple neoplasia and lentiginosis syndrome
● Also spotty pigmentation present from birth, endocrine overactivity, psammomatous melanotic schwannomas, and intraductal breast adenoma composed of long, straight, narrow, roughly parallel tubules with distinct epithelial and myoepithelial cells (Am J Surg Pathol 1991;15:722)
● Linked to PRKAR1A gene (Atlas of Genetics and Cytogenetics) at 17q23-24 (found in 46% of Carney’s syndrome cases) and CNC2 gene at 2p16 (J Med Genet 2003;40:268)
● First described in 1985 by J. Aidan Carney (Medicine (Baltimore) 1985;64:270, WhoNamedIt.com)
Terminology
=========================================================================
● Also called Carney complex
Epidemiology
=========================================================================
● Incidence of 70 cases per 100,000 individuals
● Usually white, no gender preference
● Mean age at diagnosis is 10-20 years (eMedicine)
Sites
=========================================================================
●
Etiology
=========================================================================
●
Clinical features
=========================================================================
●
Prognostic factors
=========================================================================
●
Case reports
=========================================================================
●
Treatment
=========================================================================
●
Clinical images
=========================================================================
●
Gross description (Macroscopy)
=========================================================================
●
Gross images
=========================================================================
Micro description (Histopathology)
=========================================================================
●
Micro images
=========================================================================
Drawings
=========================================================================
Virtual Slides
=========================================================================
Videos
=========================================================================
Cytology description
=========================================================================
●
Cytology images
=========================================================================
●
Positive stains
=========================================================================
●
Negative stains
=========================================================================
●
Electron microscopy descriptions
=========================================================================
●
Electron microscopy images
=========================================================================
Molecular / cytogenetics description
=========================================================================
●
Molecular / cytogenetics images
=========================================================================
Differential Diagnosis
=========================================================================
●
Additional references
=========================================================================
End of Breast-nonmalignant > Benign tumors / changes > Carney’s syndrome
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).