Breast - nonmalignant
Benign tumors / changes
Chondrolipoma of breast

Author: Monika Roychowdhury, M.D., FCAP (see Authors page)

Revised: 7 August 2017, last major update October 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chondrolipoma breast
Cite this page: Chondrolipoma of breast. website. Accessed March 19th, 2018.
Definition / general
  • Rare circumscribed lesion of mature fibrous stroma, white adipose tissue, breast ducts and mature cartilage
  • Very rare
Clinical features
  • Clinically resembles fibroadenoma but may show calcification on mammography mimicking carcinoma
  • Generally seen above the age of 50 years
Case reports
  • Excision; does not recur
Gross description
  • Well demarcated, islands of cartilage project from cut surface, resembles fibroadenoma (Breast 2006;15:425)
Gross images

Images hosted on PathOut server:
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Hand mass

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Shoulder mass

Microscopic (histologic) description
  • Mature fibrous stroma, adipose tissue, breast ducts, mature cartilage
Microscopic (histologic) images

Images hosted on PathOut server:

Hand mass:

Case of the Week #52

Soft tissue (not breast) - AFIP:
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Well circumscribed tumor composed of clusters of small to medium cells with vacuolated cytoplasm; mature fat cells are present

Cytology description
  • Mixture of benign adipose tissue with lipoblast-like cells and chondroblast-like cells with a fibrochondroid matrix
Molecular / cytogenetics description
Molecular / cytogenetics images

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3 way arrangement
with chromosomes
1, 2 and 5

Differential diagnosis
  • Liposarcoma: infiltrative; lipoblasts (may also be found in chondrolipoma) and atypia are present; different cytogenetics