Core biopsy

Topic Completed: 1 April 2010

Minor changes: 17 November 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Core biopsy [title] of breast lesions [title]

Hind Warzecha, M.D.
Page views in 2019: 2,994
Page views in 2020 to date: 2,826
Cite this page: Warzecha H. Core biopsy. website. Accessed November 23rd, 2020.
Definition / general
Core biopsy versus fine needle aspiration biopsy
Core biopsy is favored over fine needle aspiration because core biopsy:
Guidance modalities

MRI directed breast excision:

Definition / general:
Clinical features:
Technical details
False negatives
  • Radiologic - histologic correlation: must determine if histologic results provide a sufficient explanation for the imaging features - if not, lesion may not have been adequately sampled
  • Most false negatives are due to radiologic - histologic discordance and are discovered immediately (Eur Radiol 2010;20:782, Eur J Cancer 2010;46:1835)
  • Follow up imaging is recommended, even in patients with concordant benign findings (Radiographics 2007;27:79)
Reporting system of UK National Health Service Screening Programme
  • B1: normal tissue / inadequate sample (comment on microcalcifications and specimen adequacy)
  • B2: benign lesion (specify)
  • B3: uncertain malignant potential (includes radial scar, some papillary lesions, ADH, lobular neoplasia)
  • B4: suspicious of malignancy (suggestive but not diagnostic due to scanty material or artifacts)
  • B5: malignant; specify if invasive or not, if possible; indicate grade of DCIS
  • References: J Clin Pathol 2004;57:897
Diagrams / tables

Images hosted on other servers:


Microscopic (histologic) images

Images hosted on other servers:

Displaced epithelial cells; #2 - intracystic papillary carcinoma

Core biopsy with atypical hyperplasia (various)

Invasive lobular carcinoma

Detached clusters
of ductal carcinoma
in situ from
pre-existing ducts

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