Breast - nonmalignant
Benign tumors / changes
Eccrine spiradenoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 14 January 2016, last major update December 2015

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Eccrine spiradenoma [title] breast
Cite this page: Eccrine spiradenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breasteccrinespiradenoma.html. Accessed December 7th, 2016.
Definition / General
  • Rare, benign, adnexal tumor of skin first reported in 1956 (AMA Arch Derm 1956;73:199)
  • Resembles dermal counterpart, with lobules containing biphasic cell population (packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei and peripheral smaller cells with hyperchromatic nuclei)
Essential Features
  • Benign adnexal tumor
  • Circumscribed lesion with lobulated pattern composed of biphasic cell population
  • Immunostains p63+, calponin (outer cells) and CK7, CD117 (inner cells)
  • Wide local excision is curative
Epidemiology
  • Most patients in their 2nd to 4th decade
Sites
  • Usually trunk or extremities, rarely other sites
Etiology
  • Arises from cutaneous sweat glands
Clinical Features
Radiology Description
  • Although mammographic and ultrasonographic findings are similar between eccrine spiradenoma of breast and epidermal inclusion cyst, MRI findings differ and can be used to differentiate
Case Reports
Treatment
  • Wide local excision
Clinical Images

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Well defined, isodense nodule

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Hypoechoic mass

Micro Description
  • At low power, appears as a solid neoplasm composed of a single mass or a few masses of basaliod cells
  • At higher magnification, two distinct populations of neoplastic epithelial cells can be seen making a circumscribed lesion with a lobulated pattern
  • Jigsaw puzzle shaped lobules contain packed, monotonous, larger basaloid epithelial cells with scant cytoplasm and round/oval and pale nuclei
  • At periphery are smaller cells with dark hyperchromatic nuclei
  • No epidermal connection is seen
Micro Images

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Two cell population

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Deep dermis

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Site unknown

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Malignant transformation

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Various images

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p63, CK7, CD117

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Ki67

Cytology Description
  • Bland groups of uniform cuboidal cells with scant cytoplasm, round/oval nuclei, indistinct nucleoli
  • Occasional rosette-like structures (Diagn Cytopathol 1992;8:366)
Positive Stains
Negative Stains
Additional References