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Breast-nonmalignant
Benign tumors / changes
Eccrine spiradenoma
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 6 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Very rare tumor resembling dermal counterpart, with lobules containing packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei
Terminology
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Epidemiology
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Sites
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Etiology
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● Arises from cutaneous sweat glands
Clinical features
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● Benign, rarely undergoes malignant transformation (Arch Pathol Lab Med 1996;120:501)
● May be painful
Prognostic factors
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Case reports
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● 43 year old woman with 3 local recurrences (Am J Clin Pathol 1996;106:665)
● Periumbilical malignant tumor metastatic to axillary node (Breast Cancer 2008;15:175)
Treatment
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● Wide local excision
Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Circumscribed with lobulated pattern
● Lobules contain packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei
● At periphery are smaller cells with dark nuclei
Micro images
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Site unknown
Virtual Slides
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Videos
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Cytology description
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● Bland groups of uniform cuboidal cells with scant cytoplasm, round/oval nuclei, indistinct nucleoli
● Occasional rosette-like structures (Diagn Cytopathol 1992;8:366)
Cytology images
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Positive stains
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● Keratin, EMA, ER, PR
● Ki-67
Negative stains
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● Vimentin, muscle specific actin, GFAP, S100, CEA
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Eccrine spiradenoma
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