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Breast-nonmalignant

Benign tumors / changes

Eccrine spiradenoma

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 6 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Very rare tumor resembling dermal counterpart, with lobules containing packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei

 

Terminology

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Epidemiology

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Sites

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Etiology

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● Arises from cutaneous sweat glands

 

Clinical features

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● Benign, rarely undergoes malignant transformation (Arch Pathol Lab Med 1996;120:501)

● May be painful

 

Prognostic factors

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Case reports

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● 43 year old woman with 3 local recurrences (Am J Clin Pathol 1996;106:665)

● Periumbilical malignant tumor metastatic to axillary node (Breast Cancer 2008;15:175)

 

Treatment

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● Wide local excision

 

Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Circumscribed with lobulated pattern

● Lobules contain packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei

● At periphery are smaller cells with dark nuclei


Micro images
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Thigh mass: sharply demarcated lobules of benign Eccrine Spiradenoma with malignant focus shown by pointer


Site unknown

Virtual Slides

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Videos

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Cytology description

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● Bland groups of uniform cuboidal cells with scant cytoplasm, round/oval nuclei, indistinct nucleoli

● Occasional rosette-like structures (Diagn Cytopathol 1992;8:366)

 

Cytology images

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Positive stains

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● Keratin, EMA, ER, PR

● Ki-67

 

Negative stains

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● Vimentin, muscle specific actin, GFAP, S100, CEA

 

Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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eMedicine (skin)

 

End of Breast-nonmalignant > Benign tumors / changes > Eccrine spiradenoma

 

 

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