Advertisement
Advertisement
Table of Contents
Definition / general | Essential features | Epidemiology | Sites | Etiology | Clinical features | Radiology description | Case reports | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Additional referencesCite this page: Eccrine spiradenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breasteccrinespiradenoma.html. Accessed July 14th, 2017.
Definition / general
- Rare, benign, adnexal tumor of skin first reported in 1956 (AMA Arch Derm 1956;73:199)
- Resembles dermal counterpart, with lobules containing biphasic cell population (packed, monotonous, basaloid epithelial cells with scant cytoplasm and round/oval nuclei and peripheral smaller cells with hyperchromatic nuclei)
Essential features
- Benign adnexal tumor
- Circumscribed lesion with lobulated pattern composed of biphasic cell population
- Immunostains p63+, calponin (outer cells) and CK7, CD117 (inner cells)
- Wide local excision is curative
Epidemiology
- Most patients in their 2nd to 4th decade
Sites
- Usually trunk or extremities, rarely other sites
Etiology
- Arises from cutaneous sweat glands
Clinical features
- Palpable, occasionally painful lump
- Benign, rarely undergoes malignant transformation (Arch Pathol Lab Med 1996;120:501)
Radiology description
- Although mammographic and ultrasonographic findings are similar between eccrine spiradenoma of breast and epidermal inclusion cyst, MRI findings differ and can be used to differentiate
Case reports
- 39 year old woman with eccrine spiradenoma arising from breast skin (Case Rep Pathol 2015;2015:615158)
- 43 year old woman with recurring breast tumor with features of eccrine spiradenoma (Am J Clin Pathol 1996;106:665)
- 47 year old woman with eccrine spiradenoma misdiagnosed as an epidermal inclusion cyst (Korean J Radiol 2011;12:256)
- 48 year old woman with malignant eccrine breast spiradenoma (Int J Surg Case Rep 2015;15:81)
- 57 year old woman with spiradenocarcinoma of breast arising in a long standing spiradenoma (Ann Diagn Pathol 2004;8:162)
- Malignant eccrine spiradenoma metastatic to intramammary lymph node (Breast Cancer 2008;15:175)
Treatment
- Wide local excision
Clinical images
Images hosted on Other servers:
Well defined, isodense nodule
Hypoechoic mass
Microscopic (histologic) description
- At low power, appears as a solid neoplasm composed of a single mass or a few masses of basaliod cells
- At higher magnification, two distinct populations of neoplastic epithelial cells can be seen making a circumscribed lesion with a lobulated pattern
- Jigsaw puzzle shaped lobules contain packed, monotonous, larger basaloid epithelial cells with scant cytoplasm and round/oval and pale nuclei
- At periphery are smaller cells with dark hyperchromatic nuclei
- No epidermal connection is seen
Microscopic (histologic) images
Images hosted on Other servers:
Two cell population
Deep dermis
Site unknown
Malignant transformation
Various images
p63, CK7, CD117
Ki67
Cytology description
- Bland groups of uniform cuboidal cells with scant cytoplasm, round/oval nuclei, indistinct nucleoli
- Occasional rosette-like structures (Diagn Cytopathol 1992;8:366)
Additional references
Advertisement
