Breast nonmalignant
Inflammatory
Fat necrosis of breast


Topic Completed: 1 March 2010

Revised: 30 May 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Fat necrosis [title] breast

Hind Nassar, M.D.
Page views in 2018: 10,309
Page views in 2019 to date: 5,650
Cite this page: Nassar H Fat necrosis of breast. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastfatnecrosis.html. Accessed June 24th, 2019.
Definition / general
  • Partially necrotic adipose tissue with foamy macrophages, multinucleated giant cells and chronic inflammatory cells
  • Simulates carcinoma clinically and mammographically (AJR Am J Roentgenol 2009;192:815)
Clinical features
Clinical images

Images hosted on other servers:

Skin and fat necrosis due to methylene blue

Gross description
  • Opaque, bright yellow
Gross images

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Hemorrhagic fat necrosis

Microscopic (histologic) description
  • Partially necrotic adipose tissue with foamy macrophages, multinucleated giant cells and chronic inflammatory cells
  • Often hemosiderin deposits, fibrosis and calcification
  • Occasional metaplastic squamous epithelium
Microscopic (histologic) images

Contributed by Emily S. Reisenbichler, M.D.

Foamy histiocytes and occasional multinucleated giant cells surrounding cystic spaces



Contributed by Mark R. Wick, M.D.

Tumefactive (producing swelling)


AFIP images:

With metaplastic
squamous epithelium
and keratin whorls



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Foamy macrophages and calcifications

Disruption of fat, lipid laden macrophages

Infarcted fat cells


Foreign body giant cell reaction

Foreign body granuloma

Irregular fatty spaces and foamy macrophages

Giant cells

Giant cells engulfing lipid

Cytology images

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Various stages of fat necrosis

Pap stain (inset Giemsa)

Videos


Histopathology breast - fat necrosis, traumatic
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