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Breast-nonmalignant
Benign tumors / changes
Cellular fibroadenoma of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 7 October 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Resembles fibroadenoma with pericanalicular pattern but more cellular
Terminology
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● Also called juvenile fibroadenoma
● Giant fibroadenoma: terminology used inconsistently; refers to size, often children, but not a distinct histopathologic entity
Epidemiology
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● Usually black females, median age 15 years (range 10-39 years)
Etiology
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Clinical features
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● Grows rapidly but benign behavior
● Often massive size
● Either solitary or multiple/successive lesions; recurrences usually cease in 20’s
● Not associated with subsequent carcinoma
Prognostic factors
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Case reports
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● 12 year old girl (American Society of Breast Disease Winter 2005, page 11)
● 13 year old girl (The Internet Journal of Surgery 2007;12(1))
● 15 year old girl with bilateral tumors (National Institute of Oncology and Radiobiology, Cuba)
Treatment
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● Conservative excision (preserve as much normal breast tissue as possible, Saudi Med J 2007;28:137, Breast J 2000;6:418)
Clinical images
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Gross description (Macroscopy)
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● Yellow-tan, softer than classic fibroadenoma
Gross images
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Well circumscribed lobulated mass
Micro description (Histopathology)
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● Resembles fibroadenoma with pericanalicular pattern but more cellular
● Stromal and epithelial balance is not altered
● Epithelium may have tufted pattern or hyperplasia characteristic of gynecomastia; may have epithelial atypia (Am J Surg Pathol 1987;11:184)
● Usually 2-3 mitotic figures/HPF, only rarely 4+ MF/HPF
● No increase in periductal cellularity that is seen in phyllodes tumors
Micro images
Juvenile fibroadenoma
13 year old girl with rapidly growing 24 year old woman
5 cm mass and epithelial hyperplasia
Stromal and epithelial hyperplasia
Other images: #1; #2; #3; calponin, p63
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Hamartoma: more abundant adipose tissue; epithelial component is more disorganized
● Phyllodes tumor: prominent stromal overgrowth, intracanalicular growth pattern, periductal concentration of cells, variable atypia and mitotic figures
Additional references
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● Archives 1987;111:427, Stanford University
End of Breast-nonmalignant > Benign tumors / changes > Cellular (juvenile) fibroadenoma
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