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Breast-nonmalignant

Benign tumors / changes

Cellular fibroadenoma of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 7 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Resembles fibroadenoma with pericanalicular pattern but more cellular

 

Terminology

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● Also called juvenile fibroadenoma

Giant fibroadenoma: terminology used inconsistently; refers to size, often children, but not a distinct histopathologic entity

 

Epidemiology

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● Usually black females, median age 15 years (range 10-39 years)

 

Etiology

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Clinical features

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● Grows rapidly but benign behavior

● Often massive size

● Either solitary or multiple/successive lesions; recurrences usually cease in 20’s

● Not associated with subsequent carcinoma

 

Prognostic factors

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Case reports

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● 12 year old girl (American Society of Breast Disease Winter 2005, page 11)

● 13 year old girl (The Internet Journal of Surgery 2007;12(1))

● 15 year old girl with bilateral tumors (National Institute of Oncology and Radiobiology, Cuba)

 

Treatment

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● Conservative excision (preserve as much normal breast tissue as possible, Saudi Med J 2007;28:137, Breast J 2000;6:418) 

 

Clinical images

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Gross description (Macroscopy)

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● Yellow-tan, softer than classic fibroadenoma

 

Gross images

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Well circumscribed lobulated mass

 

Micro description (Histopathology)

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● Resembles fibroadenoma with pericanalicular pattern but more cellular

● Stromal and epithelial balance is not altered

● Epithelium may have tufted pattern or hyperplasia characteristic of gynecomastia; may have epithelial atypia (Am J Surg Pathol 1987;11:184)

Usually 2-3 mitotic figures/HPF, only rarely 4+ MF/HPF

● No increase in periductal cellularity that is seen in phyllodes tumors

 

Micro images

 

  

Juvenile fibroadenoma

 

 

                                                               

13 year old girl with rapidly growing                             24 year old woman

5 cm mass and epithelial hyperplasia

 

 

         

 

         

Stromal and epithelial hyperplasia

 

Other images: #1#2#3calponinp63

 

Virtual Slides

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Juvenile Fibroadenoma

 

Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Hamartoma: more abundant adipose tissue; epithelial component is more disorganized

Phyllodes tumor: prominent stromal overgrowth, intracanalicular growth pattern, periductal concentration of cells, variable atypia and mitotic figures

 

Additional references

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Archives 1987;111:427, Stanford University

 

End of Breast-nonmalignant > Benign tumors / changes > Cellular (juvenile) fibroadenoma

 

 

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