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General
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Epidemiology
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Sites
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Clinical features
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Case reports
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Treatment
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Clinical images
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Deep mammogram, courtesy of Dr. Mark R. Wick

Gross description
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Gross images
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Solid ill defined mass

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Underlying chest wall musculature, ribs, and parietal pleura

Micro description
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Micro images
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Courtesy of Dr. Mark R. Wick

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Various images

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Neoplastic infiltrate surrounds ducts and lobules

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Sparsely cellular collagenous area with lymphocytes

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Spindle cells with uniform nuclei and no mitotic activity

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Keloidal collagen surrounds atrophic duct

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Spindle cells in myxoid stroma

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Focally, cells have large hyperchromatic nuclei

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Bland spindle cells and collagen

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Mammary ductal epithelium

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Myofibroblastic spindle cells with indistinct cytoplasm, vesicular nuclei, small nucleoli and interstitial collagen

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Invading muscle

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Bland fibroblasts of moderate cellularity

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Smooth muscle actin+

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Cytokeratin negative

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Fig A: infiltration into adjacent breast tissue Fig B: infiltration into skeletal muscle Fig C: monotonous, bland spindle cells with abundant extracellular collagen, occasional small nucleoli

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Molecular / cytogenetics description
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Differential diagnosis
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End of Breast - nonmalignant > Benign tumors / changes > Fibromatosis of breast



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