General
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• Variable increase in dense connective tissue

Terminology
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• Also called hyaline fibrosis of stroma

Epidemiology
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• Common finding (2-7% of core needle biopsies, Radiology 2000;216:255, AJR Am J Roentgenol 2001;177:573)

Etiology
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• Unknown
• Associated with diabetes (Gen Diagn Pathol 1997;143:49), radiation therapy (Eur J Cancer 2008;44:2587), Cowden’s syndrome (Exp Dermatol 1998;7:380)

Clinical features
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• Non specific finding
• May be associated with a reduced risk for progression to breast cancer (Clin Cancer Res 2007;13:5474)

Treatment
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• Does not require specific therapy

Gross images
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Fibrosis

Stroma, courtesy of Dr. Mark R. Wick

Subgross

Micro description
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• Fibrous stromal proliferation with obliteration of ducts and acini

Micro images
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Stroma, courtesy of Dr. Mark R. Wick

Mass-like fibrosis with entrapped ducts and lobules

   

H&E

Fibrous tissue with dilated ducts and reduced lobules

Stromal fibrous nodule

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