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Breast-nonmalignant

Fibrosis of breast

 

Editor: Hind Nassar, MD, Johns Hopkins Medical Institute

Revised: 7 October 2012, last major update June 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Variable increase in dense connective tissue

           

Terminology

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● Also called hyaline fibrosis of stroma

 

Epidemiology

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● Common finding (2-7% of core needle biopsies, Radiology 2000;216:255, AJR Am J Roentgenol 2001;177:573)

 

Etiology

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● Unknown

● Associated with diabetes (Gen Diagn Pathol 1997;143:49), radiation therapy (Eur J Cancer 2008;44:2587), Cowden’s syndrome (Exp Dermatol 1998;7:380)

 

Clinical features

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● Non specific finding

● May be associated with a reduced risk for progression to breast cancer (Clin Cancer Res 2007;13:5474)

 

Treatment

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● Does not require specific therapy

 

Gross images

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Other images: Fibrosis

 

Micro description (Histopathology)

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● Fibrous stromal proliferation with obliteration of ducts and acini

 

Micro images

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Mass-like fibrosis with entrapped ducts and lobules

 

 

                                                               

Fibrous tissue with dilated ducts                                   Discrete lobulocentric focus

and reduced lobules                                                          of fibrous tissue (arrows)

 

 

                                                                               

Narrow bands of fibrous tissue (arrow)                       Irregular patches of fibrous tissue

surrounding ducts (arrowhead) and lobules              (arrows) mixed with fat

 

 

                                                               

Stromal fibrous nodule #1                                               #2-subgross

 

End of Breast-nonmalignant > Fibrosis of breast

 

 

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