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Breast-nonmalignant
Fibrosis of breast
Editor: Hind Nassar, MD, Johns Hopkins Medical Institute
Revised: 7 October 2012, last major update June 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Variable increase in dense connective tissue
Terminology
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● Also called hyaline fibrosis of stroma
Epidemiology
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● Common finding (2-7% of core needle biopsies, Radiology 2000;216:255, AJR Am J Roentgenol 2001;177:573)
Etiology
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● Unknown
● Associated with diabetes (Gen Diagn Pathol 1997;143:49), radiation therapy (Eur J Cancer 2008;44:2587), Cowden’s syndrome (Exp Dermatol 1998;7:380)
Clinical features
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● Non specific finding
● May be associated with a reduced risk for progression to breast cancer (Clin Cancer Res 2007;13:5474)
Treatment
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● Does not require specific therapy
Gross images
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Other images: Fibrosis
Micro description (Histopathology)
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● Fibrous stromal proliferation with obliteration of ducts and acini
Micro images
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Mass-like fibrosis with entrapped ducts and lobules
Fibrous tissue with dilated ducts Discrete lobulocentric focus
and reduced lobules of fibrous tissue (arrows)
Narrow bands of fibrous tissue (arrow) Irregular patches of fibrous tissue
surrounding ducts (arrowhead) and lobules (arrows) mixed with fat
Stromal fibrous nodule #1 #2-subgross
End of Breast-nonmalignant > Fibrosis of breast
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